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GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 [ Homo sapiens (human) ]

Gene ID: 374378, updated on 21-Dec-2019

Summary

Official Symbol
GALNT18provided by HGNC
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 18provided by HGNC
Primary source
HGNC:HGNC:30488
See related
Ensembl:ENSG00000110328 MIM:615136
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GALNT15; GALNTL4; GALNACT18; GalNAc-T15; GalNAc-T18
Expression
Broad expression in thyroid (RPKM 3.7), lung (RPKM 3.5) and 24 other tissues See more
Orthologs

Genomic context

See GALNT18 in Genome Data Viewer
Location:
11p15.4
Exon count:
16
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (11270877..11622005, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (11292421..11643561, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2752 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 22 Neighboring gene MT-ND5 pseudogene 21 Neighboring gene casein kinase 2 alpha 3 Neighboring gene Sharpr-MPRA regulatory region 8932 Neighboring gene uncharacterized LOC107983976 Neighboring gene uncharacterized LOC105376553 Neighboring gene microRNA 4299

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 4 (GALNTL4) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC71806

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
polypeptide N-acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cellular_component ND
No biological Data available
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
polypeptide N-acetylgalactosaminyltransferase 18
Names
GalNAc-transferase 18
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 4
galNAc-T-like protein 4
polypeptide GalNAc transferase 18
polypeptide GalNAc transferase-like protein 4
polypeptide N-acetylgalactosaminyltransferase-like protein 4
pp-GaNTase-like protein 4
protein-UDP acetylgalactosaminyltransferase-like protein 4
putative polypeptide N-acetylgalactosaminyltransferase-like protein 4
NP_001350393.1
NP_940918.2
XP_006718288.1
XP_011518370.1
XP_011518371.1
XP_011518372.1
XP_011518373.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363464.2NP_001350393.1  polypeptide N-acetylgalactosaminyltransferase 18 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC023946, AC084243, AC104031, AC131935
    Conserved Domains (2) summary
    cd00161
    Location:409536
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    cl11394
    Location:157396
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
  2. NM_198516.3NP_940918.2  polypeptide N-acetylgalactosaminyltransferase 18 isoform 1

    See identical proteins and their annotated locations for NP_940918.2

    Status: VALIDATED

    Source sequence(s)
    AB078147, AC131935, BC037341
    Consensus CDS
    CCDS7807.1
    UniProtKB/Swiss-Prot
    Q6P9A2
    UniProtKB/TrEMBL
    Q58A54
    Related
    ENSP00000227756.4, ENST00000227756.5
    Conserved Domains (2) summary
    cd02510
    Location:157458
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:471598
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    11270877..11622005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520068.2XP_011518370.1  polypeptide N-acetylgalactosaminyltransferase 18 isoform X2

    Conserved Domains (3) summary
    cd02510
    Location:2281
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:294421
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:292419
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
  2. XM_011520071.3XP_011518373.1  polypeptide N-acetylgalactosaminyltransferase 18 isoform X5

    Conserved Domains (1) summary
    cl11394
    Location:157365
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
  3. XM_011520070.3XP_011518372.1  polypeptide N-acetylgalactosaminyltransferase 18 isoform X4

    Conserved Domains (1) summary
    cl11394
    Location:157364
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
  4. XM_006718225.3XP_006718288.1  polypeptide N-acetylgalactosaminyltransferase 18 isoform X6

    Conserved Domains (1) summary
    cl11394
    Location:157364
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
  5. XM_011520069.3XP_011518371.1  polypeptide N-acetylgalactosaminyltransferase 18 isoform X3

    Conserved Domains (1) summary
    cl11394
    Location:157365
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
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