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NHLRC2 NHL repeat containing 2 [ Homo sapiens (human) ]

Gene ID: 374354, updated on 6-Sep-2022

Summary

Official Symbol
NHLRC2provided by HGNC
Official Full Name
NHL repeat containing 2provided by HGNC
Primary source
HGNC:HGNC:24731
See related
Ensembl:ENSG00000196865 MIM:618277; AllianceGenome:HGNC:24731
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FINCA
Summary
Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart (RPKM 7.9), thyroid (RPKM 6.2) and 25 other tissues See more
Orthologs
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Genomic context

See NHLRC2 in Genome Data Viewer
Location:
10q25.3
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (113854661..113917194)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (114746230..114808754)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (115614420..115676953)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene DNA cross-link repair 1A Neighboring gene uncharacterized LOC124902506 Neighboring gene uncharacterized LOC124902507 Neighboring gene uncharacterized LOC105378492

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20147, FLJ25621, FLJ33312, MGC45492, DKFZp779F115

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in platelet alpha granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
NHL repeat-containing protein 2
Names
1200003G01Rik
novel NHL repeat domain containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198514.4NP_940916.2  NHL repeat-containing protein 2

    See identical proteins and their annotated locations for NP_940916.2

    Status: VALIDATED

    Source sequence(s)
    AK090631, AK098487, AL162407, AL832090, BX538287
    Consensus CDS
    CCDS7585.1
    UniProtKB/Swiss-Prot
    Q8N5A6, Q8NBF2
    UniProtKB/TrEMBL
    Q7Z658
    Related
    ENSP00000358307.3, ENST00000369301.3
    Conserved Domains (2) summary
    cd03012
    Location:55182
    TlpA_like_DipZ_like; TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA ...
    cd14951
    Location:261624
    NHL-2_like; NHL repeat domain of NHL repeat-containing protein 2 and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    113854661..113917194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539769.4XP_011538071.1  NHL repeat-containing protein 2 isoform X1

    Conserved Domains (4) summary
    cd03012
    Location:55182
    TlpA_like_DipZ_like; TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA ...
    cd05819
    Location:226263
    NHL; NHL repeat [structural motif]
    cd14951
    Location:261624
    NHL-2_like; NHL repeat domain of NHL repeat-containing protein 2 and similar proteins
    cl18310
    Location:165316
    NHL; NHL repeat unit of beta-propeller proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    114746230..114808754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)