LEPR leptin receptor [Gallus gallus (chicken)] - Gene

Summary

Symbol: LEPRprovided by CGNC
Full Name: leptin receptorprovided by CGNC
Primary source: CGNC:49091
See related: Ensembl:ENSGALG00010024165
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: LPR
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	8	NC_052539.1 (28021851..28054495)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	8	NC_052580.1 (28034381..28066527)

Chromosome 8 - NC_052539.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LEPR was expressed in cerebellum, hypothalamus, cerebrum, adrenal gland, embryonic testis, ovaries, and limb bud. Low level expression was detected in adipose tissue, kidney and heart, whereas no transcripts were found in lung, breast muscle, and liver.
Title: Identification of the Long-Sought Leptin in Chicken and Duck: Expression Pattern of the Highly GC-Rich Avian leptin Fits an Autocrine/Paracrine Rather Than Endocrine Function.
Between 3 and 6 wk of age, leptin receptor expression decreased with age in adipose tissue.
Title: Expression of genes for interleukins, neuropeptides, growth hormone receptor, and leptin receptor in adipose tissue from growing broiler chickens.
In fast growing standard hens fed ad libitum and presenting significant reproductive dysfunction, dramatic up-regulation of granulosa cell expression of the leptin receptor was observed
Title: Leptin receptor in the chicken ovary: potential involvement in ovarian dysfunction of ad libitum-fed broiler breeder hens.
Tissue expression of the chicken LEPR short form was lower and more restricted than that of the LEPR long isoform, collectively these data demonstrate that the LEPR is alternatively spliced to produce at least one short isoform, as is the case in mammals.
Title: Molecular cloning and tissue distribution of a short form chicken leptin receptor mRNA.
Surface plasmon resonance analysis identified six mutants in which leptin binding activity was totally abolished
Title: Mapping leptin-interacting sites in recombinant leptin-binding domain (LBD) subcloned from chicken leptin receptor.
LEPR mRNA expressed in chicken tissues is likely to be translated.
Title: Existence of leptin receptor protein in chicken tissues: isolation of a monoclonal antibody against chicken leptin receptor.

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General gene information

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Markers

ROS0332 (e-PCR), detects polymorphism
- UniSTS:280336

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: leptin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204323.2 → NP_989654.2 leptin receptor precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000239

UniProtKB/TrEMBL

A0A8V0ZR35, Q9IBA7

Related

ENSGALP00010035912.1, ENSGALT00010058947.1

Conserved Domains (1) summary

smart00060
Location:731 → 811

FN3; Fibronectin type 3 domain