TIMP2 TIMP metallopeptidase inhibitor 2 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: TIMP2provided by CGNC
Official Full Name: TIMP metallopeptidase inhibitor 2provided by CGNC
Primary source: CGNC:49073
See related: Ensembl:ENSGALG00010029270
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	18	NC_052549.1 (10393188..10404241)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	18	NC_052590.1 (9993484..10004549)

Chromosome 18 - NC_052549.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Real-time polymerase chain reaction and western blot revealed different expression of MMP-2, -7, -9 and TIMP-2 and -3 on mRNA and protein levels, respectively, as well as activity of MMP-2 and -9 by activity assay in the oviduct parts.
Title: Involvement of matrix metalloproteinases (MMP-2, -7, -9) and their tissue inhibitors (TIMP-2, -3) in the chicken oviduct regression and recrudescence.
Protein level of MMP-9 was diminished, while MMP-7 and TIMP-3 were elevated in the oviduct of growing birds. MMP-2 and TIMP-2 protein levels remained constant, with a slight increase in MMP-2 concentration just before reaching maturity.
Title: Expression and localization of matrix metalloproteinases (MMP-2, -7, -9) and their tissue inhibitors (TIMP-2, -3) in the chicken oviduct during maturation.
Age-related changes of MMP-13 with balance of TIMPs act in concert to effect the controlled testicular remodeling and maturation.
Title: Expression of matrix metalloproteinase-13 (MMP-13) in the testes of growing and adult chicken.
These findings collectively show for the first time that multiple MMPs, ADAMs, and TIMPs appear to functionally interact during corneal development.
Title: Roles of MMP/TIMP in regulating matrix swelling and cell migration during chick corneal development.
distribution of matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitor of matrix metalloproteinase (TIMP)-1 and TIMP-2 using immunohistochemistry in the ascites syndrome of broiler chickens in a salt-induced experimental model
Title: The identification of matrix metalloproteinases and their tissue inhibitors in broiler chickens by immunohistochemistry.
TIMP-2 expression by cardiac neural crest cells initiates proMMP-2 activation important for their migration.
Title: Tissue inhibitor of metalloproteinase-2 (TIMP-2) expression during cardiac neural crest cell migration and its role in proMMP-2 activation.

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General gene information

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Homology

Homologs of the TIMP2 gene: The TIMP2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 476 organisms have orthologs with human gene TIMP2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protease binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in response to cytokine	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in response to hormone	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: metalloproteinase inhibitor 2

Names: TIMP-2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinases 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204298.2 → NP_989629.2 metalloproteinase inhibitor 2 precursor

Status: PROVISIONAL

Source sequence(s)

JAENSK010000317

UniProtKB/TrEMBL

R4GIL5

Related

ENSGALP00010043469.1, ENSGALT00010070778.1

Conserved Domains (1) summary

cd03585
Location:27 → 209

NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...