FABP4 fatty acid binding protein 4 [Gallus gallus (chicken)] - Gene

Summary

Symbol: FABP4provided by CGNC
Full Name: fatty acid binding protein 4provided by CGNC
Primary source: CGNC:11759
See related: Ensembl:ENSGALG00010002655
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: FABP; AFABP; A-FABP
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Genomic context

Location:: chromosome: 2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	2	NC_052533.1 (121036471..121039862, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	2	NC_052574.1 (121227668..121231056, complement)

Chromosome 2 - NC_052533.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cloning and characterization of the gene and its homology with other species.
Title: Cloning and characterization of chicken adipocyte fatty acid binding protein gene.
results indicated that an A-FABP gene polymorphism was associated with abdominal fat weight and percentage of abdominal fat, and the A-FABP gene could be a candidate locus or linked to a major gene(s) that affects abdominal fat content in the chicken
Title: Identification of single nucleotide polymorphism of adipocyte fatty acid-binding protein gene and its association with fatness traits in the chicken.
These findings provide fundamental data that might be useful in further study of the role of the A-FABP gene in IMF content and fatty metabolism in chickens.
Title: Association of A-FABP gene polymorphism and mRNA expression with intramuscular fat content (IMF) in Baicheng-You chicken.
A-FABP knockdown might lead to decreased lipid accumulation and upregulated expression of PPAR-gamma in chicken adipocytes.
Title: Chicken adipocyte fatty acid-binding protein knockdown affects expression of peroxisome proliferator-activated receptor γ gene during oleate-induced adipocyte differentiation.
A-FABP gene polymorphisms were associated with muscle stomach weight but no significant effect on any other trait.
Title: [Association between chicken A-FABP gene polymorphisms and growth and body composition traits].
These results suggested that chicken A-FABP might affect abdominal fat deposition through changing its expression level.
Title: Tissue expression characterization of chicken adipocyte fatty acid-binding protein and its expression difference between fat and lean birds in abdominal fat tissue.
SNPs identified with genetic potential to produce more desirable muscle with higher intramuscular fat in Beijing-You chickens
Title: Associations of A-FABP and H-FABP markers with the content of intramuscular fat in Beijing-You chicken.
Ser89Asn polymorphism may influence chicken adipocyte fatty acid-binding protein function and ultimately lipid deposition through changing the ligand-binding activity.
Title: A novel polymorphism in the chicken adipocyte fatty acid-binding protein gene (FABP4) that alters ligand-binding and correlates with fatness.
Increased mRNA expression of A-FABP is directly correlated with intramuscular fat percentage, and mRNA levels increase with age.
Title: Gene expression of heart- and adipocyte-fatty acid-binding protein and correlation with intramuscular fat in Chinese chickens.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables fatty acid binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: fatty acid-binding protein, adipocyte

Names: adipocyte fatty acid binding protein; adipocyte-type fatty acid binding protein; fatty acid binding protein 4, adipocyte

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204290.2 → NP_989621.2 fatty acid-binding protein, adipocyte

Status: PROVISIONAL

Source sequence(s)

JAENSK010000044

UniProtKB/TrEMBL

A0A1D5NYF3, Q90X55, Q90X56

Related

ENSGALP00010003841.1, ENSGALT00010006157.1

Conserved Domains (1) summary

cd19467
Location:2 → 131

FABP4; fatty acid binding protein 4

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

121036471..121039862 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

121227668..121231056 complement

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GenBank, FASTA, Sequence Viewer (Graphics)