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PER2 period circadian clock 2 [ Gallus gallus (chicken) ]

Gene ID: 374116, updated on 17-Jun-2019

Summary

Symbol
PER2provided by CGNC
Full Name
period circadian clock 2provided by CGNC
Primary source
CGNC:4112
See related
Ensembl:ENSGALG00000005521
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
gPer2
Summary
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Feb 2014]
Orthologs

Genomic context

See PER2 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
30
Annotation release Status Assembly Chr Location
104 current GRCg6a (GCF_000002315.5) 9 NC_006096.5 (5654602..5695659, complement)
103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 9 NC_006096.4 (5500202..5541395, complement)
102 previous assembly Gallus_gallus-4.0 (GCF_000002315.3) 9 NC_006096.3 (4981904..5005060, complement)

Chromosome 9 - NC_006096.5Genomic Context describing neighboring genes Neighboring gene calcium binding protein 39 Neighboring gene microRNA 1577 Neighboring gene translation initiation factor IF-2-like Neighboring gene hairy and enhancer of split 6 (Drosophila) Neighboring gene uncharacterized LOC101748697 Neighboring gene vesicle-associated membrane protein 2 (synaptobrevin 2) Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Neighboring gene uncharacterized LOC112533017

Genomic regions, transcripts, and products

Pathways from BioSystems

  • Herpes simplex infection, organism-specific biosystem (from KEGG)
    Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Herpes simplex infection, conserved biosystem (from KEGG)
    Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
transcription corepressor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
entrainment of circadian clock by photoperiod IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to light stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
period circadian protein homolog 2
Names
cPER2
circadian clock protein PERIOD 2
period circadian regulator 2
period homolog 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204262.1NP_989593.1  period circadian protein homolog 2

    See identical proteins and their annotated locations for NP_989593.1

    Status: PROVISIONAL

    Source sequence(s)
    AF246956
    UniProtKB/Swiss-Prot
    Q8QGQ8
    Conserved Domains (3) summary
    cd00130
    Location:382484
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08447
    Location:396480
    PAS_3; PAS fold
    pfam12114
    Location:11271321
    Period_C; Period protein 2/3C-terminal region

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCg6a Primary Assembly

Genomic

  1. NC_006096.5 Reference GRCg6a Primary Assembly

    Range
    5654602..5695659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015276795.2XP_015132281.1  period circadian protein homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P3Z1
    Conserved Domains (3) summary
    pfam08447
    Location:396480
    PAS_3; PAS fold
    pfam12114
    Location:11281319
    Period_C; Period protein 2/3C-terminal region
    cl26464
    Location:9081146
    Atrophin-1; Atrophin-1 family
  2. XM_015276799.2XP_015132285.1  period circadian protein homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P3Z1
    Conserved Domains (3) summary
    pfam08447
    Location:396480
    PAS_3; PAS fold
    pfam12114
    Location:11281319
    Period_C; Period protein 2/3C-terminal region
    cl26464
    Location:9081146
    Atrophin-1; Atrophin-1 family
  3. XM_025153296.1XP_025009064.1  period circadian protein homolog 2 isoform X4

    Conserved Domains (3) summary
    pfam08447
    Location:256340
    PAS_3; PAS fold
    pfam12114
    Location:9881179
    Period_C; Period protein 2/3C-terminal region
    cl26464
    Location:7681006
    Atrophin-1; Atrophin-1 family
  4. XM_015276806.2XP_015132292.1  period circadian protein homolog 2 isoform X3

    Conserved Domains (3) summary
    pfam08447
    Location:357441
    PAS_3; PAS fold
    pfam12114
    Location:10891280
    Period_C; Period protein 2/3C-terminal region
    cl26464
    Location:8691107
    Atrophin-1; Atrophin-1 family
  5. XM_015276800.2XP_015132286.1  period circadian protein homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P3Z1
    Conserved Domains (3) summary
    pfam08447
    Location:396480
    PAS_3; PAS fold
    pfam12114
    Location:11281319
    Period_C; Period protein 2/3C-terminal region
    cl26464
    Location:9081146
    Atrophin-1; Atrophin-1 family
  6. XM_025153295.1XP_025009063.1  period circadian protein homolog 2 isoform X3

    Conserved Domains (3) summary
    pfam08447
    Location:357441
    PAS_3; PAS fold
    pfam12114
    Location:10891280
    Period_C; Period protein 2/3C-terminal region
    cl26464
    Location:8691107
    Atrophin-1; Atrophin-1 family
  7. XM_015276802.2XP_015132288.1  period circadian protein homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P3Z1
    Related
    ENSGALP00000047397.1, ENSGALT00000054764.2
    Conserved Domains (3) summary
    pfam08447
    Location:396480
    PAS_3; PAS fold
    pfam12114
    Location:11281319
    Period_C; Period protein 2/3C-terminal region
    cl26464
    Location:9081146
    Atrophin-1; Atrophin-1 family
  8. XM_015276805.2XP_015132291.1  period circadian protein homolog 2 isoform X3

    Conserved Domains (3) summary
    pfam08447
    Location:357441
    PAS_3; PAS fold
    pfam12114
    Location:10891280
    Period_C; Period protein 2/3C-terminal region
    cl26464
    Location:8691107
    Atrophin-1; Atrophin-1 family
  9. XM_015276804.2XP_015132290.1  period circadian protein homolog 2 isoform X2

    Conserved Domains (3) summary
    cd00130
    Location:382484
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08447
    Location:396480
    PAS_3; PAS fold
    pfam12114
    Location:11271321
    Period_C; Period protein 2/3C-terminal region
  10. XM_015276807.2XP_015132293.1  period circadian protein homolog 2 isoform X4

    UniProtKB/TrEMBL
    A0A1D5P3Q0
    Conserved Domains (3) summary
    pfam08447
    Location:256340
    PAS_3; PAS fold
    pfam12114
    Location:9881179
    Period_C; Period protein 2/3C-terminal region
    cl26464
    Location:7681006
    Atrophin-1; Atrophin-1 family
  11. XM_025153297.1XP_025009065.1  period circadian protein homolog 2 isoform X4

    Conserved Domains (3) summary
    pfam08447
    Location:256340
    PAS_3; PAS fold
    pfam12114
    Location:9881179
    Period_C; Period protein 2/3C-terminal region
    cl26464
    Location:7681006
    Atrophin-1; Atrophin-1 family
  12. XM_015276798.2XP_015132284.1  period circadian protein homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P3Z1
    Conserved Domains (3) summary
    pfam08447
    Location:396480
    PAS_3; PAS fold
    pfam12114
    Location:11281319
    Period_C; Period protein 2/3C-terminal region
    cl26464
    Location:9081146
    Atrophin-1; Atrophin-1 family
  13. XM_025153292.1XP_025009060.1  period circadian protein homolog 2 isoform X1

    Conserved Domains (3) summary
    pfam08447
    Location:396480
    PAS_3; PAS fold
    pfam12114
    Location:11281319
    Period_C; Period protein 2/3C-terminal region
    cl26464
    Location:9081146
    Atrophin-1; Atrophin-1 family
  14. XM_025153291.1XP_025009059.1  period circadian protein homolog 2 isoform X1

    Conserved Domains (3) summary
    pfam08447
    Location:396480
    PAS_3; PAS fold
    pfam12114
    Location:11281319
    Period_C; Period protein 2/3C-terminal region
    cl26464
    Location:9081146
    Atrophin-1; Atrophin-1 family
  15. XM_025153294.1XP_025009062.1  period circadian protein homolog 2 isoform X1

    Conserved Domains (3) summary
    pfam08447
    Location:396480
    PAS_3; PAS fold
    pfam12114
    Location:11281319
    Period_C; Period protein 2/3C-terminal region
    cl26464
    Location:9081146
    Atrophin-1; Atrophin-1 family
  16. XM_015276797.2XP_015132283.1  period circadian protein homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P3Z1
    Conserved Domains (3) summary
    pfam08447
    Location:396480
    PAS_3; PAS fold
    pfam12114
    Location:11281319
    Period_C; Period protein 2/3C-terminal region
    cl26464
    Location:9081146
    Atrophin-1; Atrophin-1 family
  17. XM_015276808.2XP_015132294.1  period circadian protein homolog 2 isoform X4

    UniProtKB/TrEMBL
    A0A1D5P3Q0
    Conserved Domains (3) summary
    pfam08447
    Location:256340
    PAS_3; PAS fold
    pfam12114
    Location:9881179
    Period_C; Period protein 2/3C-terminal region
    cl26464
    Location:7681006
    Atrophin-1; Atrophin-1 family
  18. XM_025153290.1XP_025009058.1  period circadian protein homolog 2 isoform X1

    Conserved Domains (3) summary
    pfam08447
    Location:396480
    PAS_3; PAS fold
    pfam12114
    Location:11281319
    Period_C; Period protein 2/3C-terminal region
    cl26464
    Location:9081146
    Atrophin-1; Atrophin-1 family
  19. XM_025153293.1XP_025009061.1  period circadian protein homolog 2 isoform X1

    Conserved Domains (3) summary
    pfam08447
    Location:396480
    PAS_3; PAS fold
    pfam12114
    Location:11281319
    Period_C; Period protein 2/3C-terminal region
    cl26464
    Location:9081146
    Atrophin-1; Atrophin-1 family
  20. XM_015276796.2XP_015132282.1  period circadian protein homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P3Z1
    Conserved Domains (3) summary
    pfam08447
    Location:396480
    PAS_3; PAS fold
    pfam12114
    Location:11281319
    Period_C; Period protein 2/3C-terminal region
    cl26464
    Location:9081146
    Atrophin-1; Atrophin-1 family
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