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ARNTL aryl hydrocarbon receptor nuclear translocator like [ Gallus gallus (chicken) ]

Gene ID: 374115, updated on 23-Oct-2019

Summary

Symbol
ARNTLprovided by CGNC
Full Name
aryl hydrocarbon receptor nuclear translocator likeprovided by CGNC
Primary source
CGNC:4005
See related
Ensembl:ENSGALG00000005378
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
BMAL1
Summary
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. [provided by RefSeq, Jan 2014]
Orthologs

Genomic context

See ARNTL in Genome Data Viewer
Location:
chromosome: 5
Exon count:
21
Annotation release Status Assembly Chr Location
104 current GRCg6a (GCF_000002315.5) 5 NC_006092.5 (7819805..7864576, complement)
103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 5 NC_006092.4 (7560351..7605130, complement)
102 previous assembly Gallus_gallus-4.0 (GCF_000002315.3) 5 NC_006092.3 (7002814..7023534, complement)

Chromosome 5 - NC_006092.5Genomic Context describing neighboring genes Neighboring gene fatty acyl-CoA reductase 1 Neighboring gene BTB domain containing 10 Neighboring gene parathyroid hormone Neighboring gene uncharacterized LOC107053370 Neighboring gene uncharacterized LOC112532581 Neighboring gene Ras association domain family member 10

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Herpes simplex infection, organism-specific biosystem (from KEGG)
    Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Herpes simplex infection, conserved biosystem (from KEGG)
    Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
E-box binding IEA
Inferred from Electronic Annotation
more info
 
Hsp90 protein binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
aryl hydrocarbon receptor binding IEA
Inferred from Electronic Annotation
more info
 
bHLH transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
repressing transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
circadian regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
maternal process involved in parturition IEA
Inferred from Electronic Annotation
more info
 
negative regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cold-induced thermogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glucocorticoid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
oxidative stress-induced premature senescence IEA
Inferred from Electronic Annotation
more info
 
positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein acetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of cellular senescence IEA
Inferred from Electronic Annotation
more info
 
regulation of hair cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of type B pancreatic cell development IEA
Inferred from Electronic Annotation
more info
 
response to redox state ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PML body IEA
Inferred from Electronic Annotation
more info
 
chromatoid body IEA
Inferred from Electronic Annotation
more info
 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
aryl hydrocarbon receptor nuclear translocator-like protein 1
Names
BMAL1b'
bHLH-PAS transcription factor BMAL1
brain and muscle ARNT-like 1
cBMAL1
clock protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001463.2NP_001001463.1  aryl hydrocarbon receptor nuclear translocator-like protein 1

    See identical proteins and their annotated locations for NP_001001463.1

    Status: PROVISIONAL

    Source sequence(s)
    AF246957, BU372147, CR391754
    UniProtKB/Swiss-Prot
    Q9I8T7
    Related
    ENSGALP00000043635.1, ENSGALT00000078497.2
    Conserved Domains (5) summary
    smart00091
    Location:156215
    PAS; PAS domain
    cd00130
    Location:348443
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:81133
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:153260
    PAS; PAS fold
    pfam14598
    Location:346449
    PAS_11; PAS domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCg6a Primary Assembly

Genomic

  1. NC_006092.5 Reference GRCg6a Primary Assembly

    Range
    7819805..7864576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015286335.2XP_015141821.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X2

    Related
    ENSGALP00000070846.1, ENSGALT00000095064.1
    Conserved Domains (5) summary
    smart00091
    Location:149208
    PAS; PAS domain
    cd00130
    Location:341436
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:74126
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:146253
    PAS; PAS fold
    pfam14598
    Location:339442
    PAS_11; PAS domain
  2. XM_015286330.2XP_015141816.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9I8T7
    Conserved Domains (5) summary
    smart00091
    Location:156215
    PAS; PAS domain
    cd00130
    Location:348443
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:81133
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:153260
    PAS; PAS fold
    pfam14598
    Location:346449
    PAS_11; PAS domain
  3. XM_015286333.2XP_015141819.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9I8T7
    Conserved Domains (5) summary
    smart00091
    Location:156215
    PAS; PAS domain
    cd00130
    Location:348443
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:81133
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:153260
    PAS; PAS fold
    pfam14598
    Location:346449
    PAS_11; PAS domain
  4. XM_015286331.2XP_015141817.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9I8T7
    Conserved Domains (5) summary
    smart00091
    Location:156215
    PAS; PAS domain
    cd00130
    Location:348443
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:81133
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:153260
    PAS; PAS fold
    pfam14598
    Location:346449
    PAS_11; PAS domain
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