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BIRC5 baculoviral IAP repeat containing 5 [ Gallus gallus (chicken) ]

Gene ID: 374078, updated on 16-Jun-2026
Symbol
BIRC5provided by CGNC
Full Name
baculoviral IAP repeat containing 5provided by CGNC
Primary source
CGNC:6615
See related
Ensembl:ENSGALG00010018655
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
survivin
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Try the new Transcripts and proteins table
See BIRC5 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
4
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (15114607..15115752, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (15028907..15030054, complement)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene RNA polymerase III subunit F Neighboring gene double zinc ribbon and ankyrin repeat domains 1 Neighboring gene lysine acetyltransferase 14 Neighboring gene protein PET117 homolog, mitochondrial Neighboring gene uncharacterized LOC107052871

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line. Yue Z, et al. J Cell Biol, 2008 Oct 20. PMID 18936249, Free PMC Article
  2. Gene diagnosis of micrometastases in regional lymph nodes of patients with stage I non-small cell lung cancer: impact on staging and prognosis. Li J, et al. Clin Transl Oncol, 2013 Nov. PMID 23404657
  3. Survivin expression is associated with lens epithelial cell proliferation and fiber cell differentiation. Jarrin M, et al. Mol Vis, 2012. PMID 23213276, Free PMC Article
  4. MicroRNA-34a affects the occurrence of laryngeal squamous cell carcinoma by targeting the antiapoptotic gene survivin. Shen Z, et al. Med Oncol, 2012 Dec. PMID 22246523
  5. Survivin as a cell cycle-related and antiapoptotic protein in granulosa cells. Johnson AL, et al. Endocrinology, 2002 Sep. PMID 12193553

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High survivin expression is associated with lymph node micrometastasis in non-small cell lung cancer.
    Title: Gene diagnosis of micrometastases in regional lymph nodes of patients with stage I non-small cell lung cancer: impact on staging and prognosis.
  2. results showed that transfection of miR-34a mimic significantly suppressed cell proliferation with decreased survivin protein expression
    Title: MicroRNA-34a affects the occurrence of laryngeal squamous cell carcinoma by targeting the antiapoptotic gene survivin.
  3. Survivin is a dual regulator of lens epithelial cell proliferation and lens fiber cell differentiation.
    Title: Survivin expression is associated with lens epithelial cell proliferation and fiber cell differentiation.
  4. The isolation of two conditional knockouts of the survivin gene in chicken DT40 cells, is described.
    Title: Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line.
Submit: New GeneRIF Correction

Homology

Preferred Names
baculoviral IAP repeat-containing protein 5
Names
baculoviral IAP repeat-containing 5 (survivin)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012318.2 → NP_001012318.1  baculoviral IAP repeat-containing protein 5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    JAENSK010000062
    UniProtKB/TrEMBL
    F1NN48, Q9DDK0
    Related
    ENSGALP00010026959.1, ENSGALT00010045135.1
    Conserved Domains (1) summary
    pfam00653
    Location:20 → 89
    BIR; Inhibitor of Apoptosis domain

  2. NM_001012319.1 → NP_001012319.1  baculoviral IAP repeat-containing protein 5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate segment in the 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF377323, BU135446, BU355446, BX275001, CN227820
    UniProtKB/TrEMBL
    Q90ZN0
    Conserved Domains (1) summary
    pfam00653
    Location:20 → 89
    BIR; Inhibitor of Apoptosis domain

  3. NM_204235.2 → NP_989566.1  baculoviral IAP repeat-containing protein 5 isoform 3

    See identical proteins and their annotated locations for NP_989566.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon that results in a frameshift and has an alternate segment in the 3' UTR, compared to variant 1. The resulting protein (isoform 3) is shorter than isoform 1. This variant is supported by transcript evidence but there is no experimental evidence for the product of this transcript.
    Source sequence(s)
    AF377324, BU135446, BX275001, CN227820
    UniProtKB/TrEMBL
    A0A8V0Z8L7, Q90VY6
    Related
    ENSGALP00010026956.1, ENSGALT00010045129.1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    15114607..15115752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    15028907..15030054 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001012317.1: Suppressed sequence

    Description
    NM_001012317.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

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