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LMBR1 limb development membrane protein 1 [ Gallus gallus (chicken) ]

Gene ID: 373986, updated on 13-Apr-2026
Official Symbol
LMBR1provided by CGNC
Official Full Name
limb development membrane protein 1provided by CGNC
Primary source
CGNC:48990
See related
Ensembl:ENSGALG00010025097
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
LSS; TPT; ZRS; ACHP; PPD2; THYP; DIF14; SAPH1; C7orf2
Orthologs
all
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Try the new Transcripts and proteins table
See LMBR1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
20
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (8435836..8501553, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (8461264..8527094, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112531941 Neighboring gene ring finger protein 32 Neighboring gene nucleolar protein with MIF4G domain 1 Neighboring gene motor neuron and pancreas homeobox 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Association of SNP rs80659072 in the ZRS with polydactyly in Beijing You chickens. Chu Q, et al. PLoS One, 2017. PMID 29016641, Free PMC Article
  2. Identification of an alternative splicing isoform of chicken Lmbr1. Huang Y, et al. Mol Biol Rep, 2011 Oct. PMID 21161408
  3. Single nucleotide polymorphisms in chicken lmbr1 gene were associated with chicken growth and carcass traits. Huang Y, et al. Sci China C Life Sci, 2007 Feb. PMID 17393084
  4. Single nucleotide polymorphisms in the chicken Lmbr1 gene are associated with chicken polydactyly. Huang YQ, et al. Gene, 2006 Jun 7. PMID 16650944
  5. Isolation of the chicken Lmbr1 coding sequence and characterization of its role during chick limb development. Maas SA, et al. Dev Dyn, 2004 Mar. PMID 14991708

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The findings revealed that the toes of Beijing You chickens were rich and more complex than expected. The plausible mutation rs80659072 in the zone of polarizing activity regulatory sequence (ZRS) in chickens was an essential but not sufficient condition for polydactyly and polyphalangy in Beijing You chickens
    Title: Association of SNP rs80659072 in the ZRS with polydactyly in Beijing You chickens.
  2. Chicken Lmbr1 was alternatively spliced to generate multiple splice forms.
    Title: Identification of an alternative splicing isoform of chicken Lmbr1.
  3. Lmbr1 is not required for normal chick limb development
    Title: Isolation of the chicken Lmbr1 coding sequence and characterization of its role during chick limb development.
  4. Lmbr1 gene could be a genetic locus or linked to a major gene significantly affecting growth and carcass traits in chickens.
    Title: Single nucleotide polymorphisms in chicken lmbr1 gene were associated with chicken growth and carcass traits.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
limb region 1 protein homolog
Names
differentiation-related gene 14 protein
limb region 1 homolog

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204172.2 → NP_989503.2  limb region 1 protein homolog

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000036
    UniProtKB/TrEMBL
    A0A8V0ZWB4
    Related
    ENSGALP00010037874.1, ENSGALT00010061244.1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    8435836..8501553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046917138.1 → XP_046773094.1  limb region 1 protein homolog isoform X1

  2. XM_046917134.1 → XP_046773090.1  limb region 1 protein homolog isoform X1

  3. XM_046917136.1 → XP_046773092.1  limb region 1 protein homolog isoform X1

  4. XM_040674120.2 → XP_040530054.1  limb region 1 protein homolog isoform X2

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    8461264..8527094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046910182.1 → XP_046766138.1  limb region 1 protein homolog isoform X3

    UniProtKB/Swiss-Prot
    B2CW63, E0W5S4, E0W5S5, E0W5S6, E0W5S7, Q7ZUA6, Q7ZZZ1, Q90WF5
    UniProtKB/TrEMBL
    A0A8V0ZWB4

  2. XM_046910185.1 → XP_046766141.1  limb region 1 protein homolog isoform X1

  3. XM_046910183.1 → XP_046766139.1  limb region 1 protein homolog isoform X1

  4. XM_046910184.1 → XP_046766140.1  limb region 1 protein homolog isoform X1

  5. XM_046910187.1 → XP_046766143.1  limb region 1 protein homolog isoform X2

  6. XM_046910186.1 → XP_046766142.1  limb region 1 protein homolog isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZUA6.1 GenPept UniProtKB/Swiss-Prot:Q7ZUA6

Gene LinkOut

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Research Materials