IL2 interleukin 15 [Gallus gallus (chicken)] - Gene

Summary

Symbol: IL2provided by CGNC
Full Name: interleukin 15provided by CGNC
Primary source: CGNC:48979
See related: Ensembl:ENSGALG00010004232
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: IL-2; interleukin-2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	4	NC_052535.1 (53232430..53235481)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	4	NC_052576.1 (53235004..53238053)

Chromosome 4 - NC_052535.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

zearalenone affects IL-2, IL-6, and IFN-gamma mRNA levels in the splenic lymphocytes of chickens
Title: Effects of zearalenone on IL-2, IL-6, and IFN-γ mRNA levels in the splenic lymphocytes of chickens.
The results show that cells stimulated to produce IFN-alpha and IFN-gamma enter the circulating blood but those stimulated to produce IL-2 do not, or in very low number, and the IFN responses to both vaccines are the same.
Title: Abundance of IFN-α and IFN-γ gene transcripts and absence of IL-2 transcripts in the blood of chickens vaccinated with live or inactivated NDV.
The predicted tertiary structure of IL-2 reveals that domain I was positioned in the long A-B loop and the N terminal of Helix B, domain II was mostly situated in Helix C, and domain III was distributed in the C-D loop and Helix D.
Title: Identification of functional domains of chicken interleukin 2.
These data provide experimental evidence for elucidating the interaction between chicken CD132 and IL-2.
Title: Identification of the functional interleukin-2 binding domain of the chicken common cytokine receptor gamma chain.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables cytokine receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neutrophil activation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cytokine production	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-2

Names: interleukin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.