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NBL1 neuroblastoma 1, DAN family BMP antagonist [ Gallus gallus (chicken) ]

Gene ID: 373952, updated on 13-Apr-2026
Official Symbol
NBL1provided by CGNC
Official Full Name
neuroblastoma 1, DAN family BMP antagonistprovided by CGNC
Primary source
CGNC:2967
See related
Ensembl:ENSGALG00010020636
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
DAN
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See NBL1 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
5
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 21 NC_052552.1 (4762283..4771648)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 21 NC_052593.1 (4795525..4804882)

Chromosome 21 - NC_052552.1Genomic Context describing neighboring genes Neighboring gene capping actin protein of muscle Z-line beta subunit Neighboring gene mitochondrial inner membrane organizing system 1 Neighboring gene 5-hydroxytryptamine receptor 6 Neighboring gene transmembrane and coiled-coil domains 4 Neighboring gene ring finger protein 186

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. DAN (NBL1) promotes collective neural crest migration by restraining uncontrolled invasion. McLennan R, et al. J Cell Biol, 2017 Oct 2. PMID 28811280, Free PMC Article
  2. DAN directs endolymphatic sac and duct outgrowth in the avian inner ear. Gerlach-Bank LM, et al. Dev Dyn, 2004 Feb. PMID 14745948
  3. Cloning and expression analysis of the chick DAN gene, an antagonist of the BMP family of growth factors. Gerlach-Bank LM, et al. Dev Dyn, 2002 May. PMID 11984879
  4. Expression of the Dan gene during chicken embryonic development. Ogita J, et al. Mech Dev, 2001 Dec. PMID 11731250
  5. BMP inhibition by DAN in Hensen's node is a critical step for the establishment of left-right asymmetry in the chick embryo. Katsu K, et al. Dev Biol, 2012 Mar 1. PMID 22202776

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results identify DAN as a novel factor that inhibits uncontrolled neural crest and metastatic melanoma invasion and promotes collective migration in a manner consistent with the inhibition of BMP signaling.
    Title: DAN (NBL1) promotes collective neural crest migration by restraining uncontrolled invasion.
  2. Data show that regulation of asymmetric Dan expression by SHH and BMP4 in Hensen's node.
    Title: BMP inhibition by DAN in Hensen's node is a critical step for the establishment of left-right asymmetry in the chick embryo.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables BMP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor ligand activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
neuroblastoma suppressor of tumorigenicity 1
Names
cDAN
cysteine knot secreted protein DAN
neuroblastoma, suppression of tumorigenicity 1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204149.5 → NP_989480.2  neuroblastoma suppressor of tumorigenicity 1 precursor

    See identical proteins and their annotated locations for NP_989480.2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000329
    UniProtKB/TrEMBL
    A0A8V0ZF40
    Related
    ENSGALP00010029436.1, ENSGALT00010049821.1
    Conserved Domains (1) summary
    pfam03045
    Location:39 → 137
    DAN; DAN domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052552.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    4762283..4771648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040651090.2 → XP_040507024.1  neuroblastoma suppressor of tumorigenicity 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8QGI6, Q90YC9
    Conserved Domains (1) summary
    cl21545
    Location:40 → 122
    GHB_like; Glycoprotein hormone beta chain homologues

  2. XM_040651089.2 → XP_040507023.1  neuroblastoma suppressor of tumorigenicity 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8QGI6, Q90YC9
    Conserved Domains (1) summary
    cl21545
    Location:40 → 122
    GHB_like; Glycoprotein hormone beta chain homologues

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052593.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    4795525..4804882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046931118.1 → XP_046787074.1  neuroblastoma suppressor of tumorigenicity 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8QGI6, Q90YC9

  2. XM_046931117.1 → XP_046787073.1  neuroblastoma suppressor of tumorigenicity 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8QGI6, Q90YC9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90YC9.2 GenPept UniProtKB/Swiss-Prot:Q90YC9

Gene LinkOut

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