Format

Send to:

Choose Destination

ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 [ Gallus gallus (chicken) ]

Gene ID: 373925, updated on 14-Feb-2019

Summary

Official Symbol
ARNTL2provided by CGNC
Official Full Name
aryl hydrocarbon receptor nuclear translocator-like 2provided by CGNC
Primary source
CGNC:10520
See related
Ensembl:ENSGALG00000014096
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Summary
This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. [provided by RefSeq, Feb 2014]
Orthologs

Genomic context

See ARNTL2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
22
Annotation release Status Assembly Chr Location
104 current GRCg6a (GCF_000002315.5) 1 NC_006088.5 (68130352..68167202)
103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 1 NC_006088.4 (68192300..68229112)
102 previous assembly Gallus_gallus-4.0 (GCF_000002315.3) 1 NC_006088.3 (68281323..68317439)

Chromosome 1 - NC_006088.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107054071 Neighboring gene serine/threonine kinase 38 like Neighboring gene uncharacterized LOC107054070 Neighboring gene PPFIA binding protein 1 Neighboring gene cytochrome b5 reductase 1 Neighboring gene endonuclease, polyU-specific-like

Genomic regions, transcripts, and products

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
E-box binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
positive regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
aryl hydrocarbon receptor nuclear translocator-like protein 2
Names
brain and muscle ARNT-like 2
cBMAL2
transcription factor BMAL2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204133.1NP_989464.1  aryl hydrocarbon receptor nuclear translocator-like protein 2

    See identical proteins and their annotated locations for NP_989464.1

    Status: PROVISIONAL

    Source sequence(s)
    AF246958
    UniProtKB/Swiss-Prot
    Q8QGQ7
    Related
    ENSGALP00000022780.3, ENSGALT00000022820.4
    Conserved Domains (5) summary
    smart00091
    Location:166228
    PAS; PAS domain
    cd00130
    Location:353452
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:94146
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:166273
    PAS; PAS fold
    pfam14598
    Location:355462
    PAS_11; PAS domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCg6a Primary Assembly

Genomic

  1. NC_006088.5 Reference GRCg6a Primary Assembly

    Range
    68130352..68167202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015289880.2XP_015145366.1  aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform X4

    Conserved Domains (5) summary
    smart00091
    Location:194256
    PAS; PAS domain
    cd00130
    Location:333432
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:122174
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:194295
    PAS; PAS fold
    pfam14598
    Location:335437
    PAS_11; PAS domain
  2. XM_015289844.2XP_015145330.1  aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform X1

    Conserved Domains (5) summary
    smart00091
    Location:194256
    PAS; PAS domain
    cd00130
    Location:381480
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:122174
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:194301
    PAS; PAS fold
    pfam14598
    Location:383485
    PAS_11; PAS domain
  3. XM_015289853.2XP_015145339.1  aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform X2

    Conserved Domains (5) summary
    smart00091
    Location:194256
    PAS; PAS domain
    cd00130
    Location:377476
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:122174
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:194297
    PAS; PAS fold
    pfam14598
    Location:379481
    PAS_11; PAS domain
  4. XM_015289859.2XP_015145345.1  aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform X3

    Conserved Domains (3) summary
    smart00091
    Location:156218
    PAS; PAS domain
    pfam00010
    Location:84136
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:345447
    PAS_3; PAS fold
  5. XM_015289857.2XP_015145343.1  aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform X3

    Conserved Domains (3) summary
    smart00091
    Location:156218
    PAS; PAS domain
    pfam00010
    Location:84136
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:345447
    PAS_3; PAS fold
  6. XM_025148849.1XP_025004617.1  aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform X5

    Related
    ENSGALP00000071452.1, ENSGALT00000092969.1
    Conserved Domains (3) summary
    smart00091
    Location:128190
    PAS; PAS domain
    pfam00010
    Location:56108
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:317419
    PAS_3; PAS fold
  7. XM_015289868.2XP_015145354.1  aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform X3

    Conserved Domains (3) summary
    smart00091
    Location:156218
    PAS; PAS domain
    pfam00010
    Location:84136
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:345447
    PAS_3; PAS fold
  8. XM_015289865.2XP_015145351.1  aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform X3

    Conserved Domains (3) summary
    smart00091
    Location:156218
    PAS; PAS domain
    pfam00010
    Location:84136
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:345447
    PAS_3; PAS fold
  9. XM_025148783.1XP_025004551.1  aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform X3

    Conserved Domains (3) summary
    smart00091
    Location:156218
    PAS; PAS domain
    pfam00010
    Location:84136
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:345447
    PAS_3; PAS fold
  10. XM_015289873.2XP_015145359.1  aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform X3

    Conserved Domains (3) summary
    smart00091
    Location:156218
    PAS; PAS domain
    pfam00010
    Location:84136
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:345447
    PAS_3; PAS fold

RNA

  1. XR_003074292.1 RNA Sequence

Support Center