NRG1 neuregulin 1 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: NRG1provided by CGNC
Official Full Name: neuregulin 1provided by CGNC
Primary source: CGNC:11493
See related: Ensembl:ENSGALG00010013914
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: pro-neuregulin-1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: Z

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	Z	NC_052572.1 (54642186..55109784, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	Z	NC_059536.1 (54642186..55109784, complement)

Chromosome Z - NC_052572.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

trophic factor NRG1 is a chemoattractant through in vitro chemotaxis assays and in vivo silencing via a DN-erbB receptor
Title: Neuregulin-1 is a chemoattractant and chemokinetic molecule for trunk neural crest cells.
while NRG1 may not be critical for overall development, it appears to be important in fine-tuning pre-, post-, and perisynaptic development of the NMJ
Title: Neuregulin1 fine-tunes pre-, post-, and perisynaptic neuromuscular junction development.
Expression of NRG1 was studied in embryos and chicks. NRG1 in spinal motor neurons is developmentally regulated and depends on the maintenance of nerve-muscle interactions.
Title: Neuregulin-1 is concentrated in the postsynaptic subsurface cistern of C-bouton inputs to α-motoneurons and altered during motoneuron diseases.
Findings implicate that PKC delta isoform as an important factor for the cleavage and neurotrophin-regulated release of soluble NRG1 forms that have important effects in nervous system development and disease.
Title: Neurotrophins induce neuregulin release through protein kinase Cdelta activation.
Matrix interactions between exogenously supplied agrin and neuregulin-1 on the muscle surface provide a localized source of signaling factors needed to produce high densities of AChRs at neuromuscular junctions.
Title: Synergistic effects of neuregulin and agrin on muscle acetylcholine receptor expression.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables chemorepellent activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein tyrosine kinase activator activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in animal organ development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: pro-neuregulin-1, membrane-bound isoform

Names: pro-NRG1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204117.2 → NP_989448.1 pro-neuregulin-1, membrane-bound isoform

See identical proteins and their annotated locations for NP_989448.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000095

UniProtKB/Swiss-Prot

Q05199

Related

ENSGALP00010019695.1, ENSGALT00010033386.1

Conserved Domains (2) summary

cd00054
Location:232 → 264

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam02158
Location:282 → 673

Neuregulin; Neuregulin family

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

54642186..55109784 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040655319.2 → XP_040511253.2 pro-neuregulin-1, membrane-bound isoform isoform X16

UniProtKB/Swiss-Prot

O73750, O73751, O73752, Q05199

Related

ENSGALP00010019719.1, ENSGALT00010033423.1
XM_025144625.3 → XP_025000393.2 pro-neuregulin-1, membrane-bound isoform isoform X15

UniProtKB/TrEMBL

A0A8V0YP05

Conserved Domains (3) summary

PHA03099
Location:189 → 278

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

smart00409
Location:83 → 170

IG; Immunoglobulin

cd00054
Location:197 → 229

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_015280406.4 → XP_015135892.2 pro-neuregulin-1, membrane-bound isoform isoform X14

UniProtKB/TrEMBL

A0A8V0YP05

Conserved Domains (2) summary

smart00409
Location:83 → 170

IG; Immunoglobulin

cd00054
Location:197 → 229

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_025144624.3 → XP_025000392.2 pro-neuregulin-1, membrane-bound isoform isoform X13

UniProtKB/TrEMBL

A0A8V0YP05, A0A8V0YU12

Related

ENSGALP00010019711.1, ENSGALT00010033411.1

Conserved Domains (2) summary

smart00409
Location:83 → 170

IG; Immunoglobulin

cd00054
Location:197 → 229

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_015280405.4 → XP_015135891.2 pro-neuregulin-1, membrane-bound isoform isoform X12

UniProtKB/TrEMBL

A0A8V0YM72, A0A8V0YP05

Related

ENSGALP00010019707.1, ENSGALT00010033406.1

Conserved Domains (2) summary

smart00409
Location:83 → 170

IG; Immunoglobulin

cd00054
Location:214 → 246

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_025144623.3 → XP_025000391.2 pro-neuregulin-1, membrane-bound isoform isoform X11

UniProtKB/TrEMBL

A0A8V0YP05

Conserved Domains (2) summary

smart00409
Location:83 → 170

IG; Immunoglobulin

cd00054
Location:214 → 246

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_015280404.4 → XP_015135890.2 pro-neuregulin-1, membrane-bound isoform isoform X10

UniProtKB/TrEMBL

A0A8V0YP05

Conserved Domains (3) summary

PHA03099
Location:223 → 312

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

smart00409
Location:83 → 170

IG; Immunoglobulin

cd00054
Location:231 → 263

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_015280397.4 → XP_015135883.2 pro-neuregulin-1, membrane-bound isoform isoform X5

UniProtKB/TrEMBL

A0A8V0YP05

Related

ENSGALP00010019725.1, ENSGALT00010033439.1

Conserved Domains (2) summary

smart00409
Location:83 → 170

IG; Immunoglobulin

cd00054
Location:231 → 263

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_015280402.4 → XP_015135888.2 pro-neuregulin-1, membrane-bound isoform isoform X8

UniProtKB/TrEMBL

A0A8V0YP05

Conserved Domains (3) summary

PHA03099
Location:223 → 315

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

smart00409
Location:83 → 170

IG; Immunoglobulin

cd00054
Location:231 → 263

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_025144620.3 → XP_025000388.2 pro-neuregulin-1, membrane-bound isoform isoform X2

UniProtKB/TrEMBL

A0A8V0YP05

Conserved Domains (2) summary

smart00409
Location:83 → 170

IG; Immunoglobulin

cd00054
Location:231 → 263

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_040655320.2 → XP_040511254.1 pro-neuregulin-1, membrane-bound isoform isoform X17

UniProtKB/TrEMBL

A0A8V0YLU1

Conserved Domains (1) summary

cd00054
Location:31 → 63

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_015280403.4 → XP_015135889.2 pro-neuregulin-1, membrane-bound isoform isoform X9

Related

ENSGALP00010019688.1, ENSGALT00010033374.1

Conserved Domains (3) summary

PHA03099
Location:193 → 313

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam00008
Location:232 → 262

EGF; EGF-like domain

pfam02158
Location:306 → 659

Neuregulin; Neuregulin family
XM_015280398.4 → XP_015135884.2 pro-neuregulin-1, membrane-bound isoform isoform X6

Conserved Domains (1) summary

cd00054
Location:232 → 264

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_015280401.4 → XP_015135887.2 pro-neuregulin-1, membrane-bound isoform isoform X7

UniProtKB/TrEMBL

A0A8V0YLS0

Related

ENSGALP00010019699.1, ENSGALT00010033393.1

Conserved Domains (1) summary

cd00054
Location:232 → 264

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_046905173.1 → XP_046761129.1 pro-neuregulin-1, membrane-bound isoform isoform X3
XM_025144621.3 → XP_025000389.2 pro-neuregulin-1, membrane-bound isoform isoform X4

Conserved Domains (1) summary

cd00054
Location:232 → 264

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_025144618.3 → XP_025000386.2 pro-neuregulin-1, membrane-bound isoform isoform X1

Conserved Domains (1) summary

cd00054
Location:232 → 264

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_025144628.3 → XP_025000396.2 pro-neuregulin-1, membrane-bound isoform isoform X19

Conserved Domains (1) summary

smart00409
Location:83 → 170

IG; Immunoglobulin
XM_040655323.2 → XP_040511257.1 pro-neuregulin-1, membrane-bound isoform isoform X18

Conserved Domains (1) summary

smart00409
Location:83 → 170

IG; Immunoglobulin

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

54642186..55109784 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046934628.1 → XP_046790584.1 pro-neuregulin-1, membrane-bound isoform isoform X16

UniProtKB/Swiss-Prot

O73750, O73751, O73752, Q05199
XM_046934627.1 → XP_046790583.1 pro-neuregulin-1, membrane-bound isoform isoform X15

UniProtKB/TrEMBL

A0A8V0YP05
XM_046934626.1 → XP_046790582.1 pro-neuregulin-1, membrane-bound isoform isoform X14

UniProtKB/TrEMBL

A0A8V0YP05
XM_046934625.1 → XP_046790581.1 pro-neuregulin-1, membrane-bound isoform isoform X13

UniProtKB/TrEMBL

A0A8V0YP05, A0A8V0YU12
XM_046934624.1 → XP_046790580.1 pro-neuregulin-1, membrane-bound isoform isoform X12

UniProtKB/TrEMBL

A0A8V0YM72, A0A8V0YP05
XM_046934623.1 → XP_046790579.1 pro-neuregulin-1, membrane-bound isoform isoform X11

UniProtKB/TrEMBL

A0A8V0YP05
XM_046934622.1 → XP_046790578.1 pro-neuregulin-1, membrane-bound isoform isoform X10

UniProtKB/TrEMBL

A0A8V0YP05
XM_046934617.1 → XP_046790573.1 pro-neuregulin-1, membrane-bound isoform isoform X5

UniProtKB/TrEMBL

A0A8V0YP05
XM_046934620.1 → XP_046790576.1 pro-neuregulin-1, membrane-bound isoform isoform X8

UniProtKB/TrEMBL

A0A8V0YP05
XM_046934614.1 → XP_046790570.1 pro-neuregulin-1, membrane-bound isoform isoform X2

UniProtKB/TrEMBL

A0A8V0YP05
XM_046934629.1 → XP_046790585.1 pro-neuregulin-1, membrane-bound isoform isoform X17

UniProtKB/TrEMBL

A0A8V0YLU1
XM_046934621.1 → XP_046790577.1 pro-neuregulin-1, membrane-bound isoform isoform X9
XM_046934618.1 → XP_046790574.1 pro-neuregulin-1, membrane-bound isoform isoform X6
XM_046934619.1 → XP_046790575.1 pro-neuregulin-1, membrane-bound isoform isoform X7

UniProtKB/TrEMBL

A0A8V0YLS0
XM_046934615.1 → XP_046790571.1 pro-neuregulin-1, membrane-bound isoform isoform X3
XM_046934616.1 → XP_046790572.1 pro-neuregulin-1, membrane-bound isoform isoform X4
XM_046934613.1 → XP_046790569.1 pro-neuregulin-1, membrane-bound isoform isoform X1
XM_046934631.1 → XP_046790587.1 pro-neuregulin-1, membrane-bound isoform isoform X19
XM_046934630.1 → XP_046790586.1 pro-neuregulin-1, membrane-bound isoform isoform X18