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Cht8 Chitinase 8 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37390, updated on 2-Nov-2024

Summary

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Official Symbol
Cht8provided by FlyBase
Official Full Name
Chitinase 8provided by FlyBase
Primary source
FLYBASE:FBgn0034580
Locus tag
Dmel_CG9357
See related
AllianceGenome:FB:FBgn0034580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9357; Cht; cht8; DmCht8; Dmel\CG9357
Summary
Predicted to enable chitin binding activity and chitinase activity. Involved in ecdysis, chitin-based cuticle. Predicted to be active in extracellular region. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Cht8 in Genome Data Viewer
Location:
57B16-57B16; 2-92 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21061646..21063212)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16949151..16950717)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene capping protein alpha Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene Chitinase 12 Neighboring gene Chitinase 4 Neighboring gene antisense RNA:CR44703 Neighboring gene Chitinase 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Involvement of mind the gap in the organization of the tracheal apical extracellular matrix in Drosophila and Nilaparvata lugens. Yue XZ, et al. Insect Sci, 2020 Aug. PMID 31240817
  2. Computational identification of novel chitinase-like proteins in the Drosophila melanogaster genome. Zhu Q, et al. Bioinformatics, 2004 Jan 22. PMID 14734306
  3. The biology of insect chitinases and their roles at chitinous cuticles. Rabadiya D, et al. Insect Biochem Mol Biol, 2024 Feb. PMID 38184175
  4. Chitinase family GH18: evolutionary insights from the genomic history of a diverse protein family. Funkhouser JD, et al. BMC Evol Biol, 2007 Jun 26. PMID 17594485, Free PMC Article
  5. Manual curation and phylogenetic analysis of chitinase family genes in the Asian citrus psyllid, Diaphorina citri. Shippy TD, et al. GigaByte, 2022. PMID 36824529, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chitin binding IEA
Inferred from Electronic Annotation
more info
  
enables chitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chitin catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ecdysis, chitin-based cuticle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
chitinase 8
Names
CG9357-PA
Cht8-PA
NP_611542.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21061646..21063212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137698.1 → NP_611542.2  chitinase 8 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611542.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W2M7
    Related
    FBpp0071463, FBtr0071534
    Conserved Domains (3) summary
    cd02872
    Location:31 → 400
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00636
    Location:31 → 379
    Glyco_18; Glyco_18 domain
    pfam01607
    Location:424 → 476
    CBM_14; Chitin binding Peritrophin-A domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MSI4 Q8MSI4
Q9W2M7 Q9W2M7

Gene LinkOut

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