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MUSK muscle associated receptor tyrosine kinase [ Gallus gallus (chicken) ]

Gene ID: 373897, updated on 3-Dec-2024
Official Symbol
MUSKprovided by CGNC
Official Full Name
muscle associated receptor tyrosine kinaseprovided by CGNC
Primary source
CGNC:11730
See related
Ensembl:ENSGALG00010005790
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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See MUSK in Genome Data Viewer
Location:
chromosome: Z
Exon count:
21
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (67362599..67455625)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (67362599..67455625)

Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107052410 Neighboring gene uncharacterized LOC121108563 Neighboring gene sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 Neighboring gene lysophosphatidic acid receptor 1 Neighboring gene PHD finger protein 7-like

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Cloning and characterization of muscle-specific kinase in chicken. Ip FC, et al. Mol Cell Neurosci, 2000 Nov. PMID 11083926
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
muscle, skeletal receptor tyrosine protein kinase
Names
muscle, skeletal, receptor tyrosine kinase
muscle-specific kinase receptor
muscle-specific tyrosine protein kinase receptor
skeletal receptor tyrosine protein kinase
NP_989439.2
XP_040511246.1
XP_040511247.1
XP_040511248.1
XP_040511249.1
XP_040511250.1
XP_046761128.1
XP_046790563.1
XP_046790564.1
XP_046790565.1
XP_046790566.1
XP_046790567.1
XP_046790568.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204108.2 → NP_989439.2  muscle, skeletal receptor tyrosine protein kinase precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000095
    UniProtKB/Swiss-Prot
    Q8AXY6
    UniProtKB/TrEMBL
    A0A8V0XN86
    Related
    ENSGALP00010008162.1, ENSGALT00010013797.1
    Conserved Domains (7) summary
    cd05050
    Location:649 → 936
    PTKc_Musk; Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase
    cd07469
    Location:313 → 458
    CRD_TK_ROR_related; Cysteine-rich domain of proteins similar to tyrosine kinase-like orphan receptors
    smart00408
    Location:226 → 289
    IGc2; Immunoglobulin C-2 Type
    smart00130
    Location:463 → 545
    KR; Kringle domain
    smart00409
    Location:127 → 208
    IG; Immunoglobulin
    cd00096
    Location:57 → 63
    Ig; Ig strand C [structural motif]
    cl11960
    Location:48 → 111
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    67362599..67455625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040655313.2 → XP_040511247.1  muscle, skeletal receptor tyrosine protein kinase isoform X3

    UniProtKB/Swiss-Prot
    Q8AXY6
    Conserved Domains (6) summary
    cd05050
    Location:531 → 818
    PTKc_Musk; Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase
    cd07469
    Location:195 → 340
    CRD_TK_ROR_related; Cysteine-rich domain of proteins similar to tyrosine kinase-like orphan receptors
    smart00408
    Location:108 → 171
    IGc2; Immunoglobulin C-2 Type
    smart00130
    Location:345 → 427
    KR; Kringle domain
    smart00409
    Location:9 → 90
    IG; Immunoglobulin
    cd00096
    Location:102 → 106
    Ig; Ig strand A' [structural motif]

  2. XM_046905172.1 → XP_046761128.1  muscle, skeletal receptor tyrosine protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8V0XVU9

  3. XM_040655312.1 → XP_040511246.1  muscle, skeletal receptor tyrosine protein kinase isoform X2

    UniProtKB/Swiss-Prot
    Q8AXY6
    Conserved Domains (7) summary
    cd05050
    Location:632 → 919
    PTKc_Musk; Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase
    cd07469
    Location:296 → 441
    CRD_TK_ROR_related; Cysteine-rich domain of proteins similar to tyrosine kinase-like orphan receptors
    smart00408
    Location:209 → 272
    IGc2; Immunoglobulin C-2 Type
    smart00130
    Location:446 → 528
    KR; Kringle domain
    smart00409
    Location:110 → 191
    IG; Immunoglobulin
    cd00096
    Location:40 → 46
    Ig; Ig strand C [structural motif]
    cl11960
    Location:31 → 94
    Ig; Immunoglobulin domain

  4. XM_040655315.1 → XP_040511249.1  muscle, skeletal receptor tyrosine protein kinase isoform X4

    Conserved Domains (3) summary
    cd05050
    Location:236 → 523
    PTKc_Musk; Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase
    smart00130
    Location:50 → 132
    KR; Kringle domain
    cl02447
    Location:1 → 45
    CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

  5. XM_040655316.1 → XP_040511250.1  muscle, skeletal receptor tyrosine protein kinase isoform X4

    Conserved Domains (3) summary
    cd05050
    Location:236 → 523
    PTKc_Musk; Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase
    smart00130
    Location:50 → 132
    KR; Kringle domain
    cl02447
    Location:1 → 45
    CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

  6. XM_040655314.1 → XP_040511248.1  muscle, skeletal receptor tyrosine protein kinase isoform X4

    Conserved Domains (3) summary
    cd05050
    Location:236 → 523
    PTKc_Musk; Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase
    smart00130
    Location:50 → 132
    KR; Kringle domain
    cl02447
    Location:1 → 45
    CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    67362599..67455625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046934609.1 → XP_046790565.1  muscle, skeletal receptor tyrosine protein kinase isoform X3

    UniProtKB/Swiss-Prot
    Q8AXY6

  2. XM_046934607.1 → XP_046790563.1  muscle, skeletal receptor tyrosine protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8V0XVU9

  3. XM_046934608.1 → XP_046790564.1  muscle, skeletal receptor tyrosine protein kinase isoform X2

    UniProtKB/Swiss-Prot
    Q8AXY6

  4. XM_046934611.1 → XP_046790567.1  muscle, skeletal receptor tyrosine protein kinase isoform X4

  5. XM_046934612.1 → XP_046790568.1  muscle, skeletal receptor tyrosine protein kinase isoform X4

  6. XM_046934610.1 → XP_046790566.1  muscle, skeletal receptor tyrosine protein kinase isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8AXY6.1 GenPept UniProtKB/Swiss-Prot:Q8AXY6

Gene LinkOut

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