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ada2a adenosine deaminase 2a [ Danio rerio (zebrafish) ]

Gene ID: 373884, updated on 2-Nov-2024

Summary

Official Symbol
ada2aprovided by ZNC
Official Full Name
adenosine deaminase 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030902-4
See related
Ensembl:ENSDARG00000051746 AllianceGenome:ZFIN:ZDB-GENE-030902-4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cecr1; cecr1a; fj65e02; wu:fj65e02
Summary
Predicted to enable several functions, including adenosine deaminase activity; proteoglycan binding activity; and zinc ion binding activity. Predicted to be involved in adenosine catabolic process and inosine biosynthetic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; gill; kidney; liver; and notochord. Human ortholog(s) of this gene implicated in Sneddon syndrome. Orthologous to human ADA2 (adenosine deaminase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See ada2a in Genome Data Viewer
Location:
chromosome: 25
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (16689638..16700924)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (16593238..16604524)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 18 Neighboring gene CECR2 histone acetyl-lysine reader Neighboring gene polypeptide N-acetylgalactosaminyltransferase 8a, tandem duplicate 2 Neighboring gene probable polypeptide N-acetylgalactosaminyltransferase 8

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 2'-deoxyadenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables adenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables adenosine deaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables adenosine receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables deaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables proteoglycan binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in adenosine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within adenosine catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in adenosine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in inosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
adenosine deaminase 2-A
Names
ADA2-1
adenosine deaminase CECR1-A
cat eye syndrome chromosome region, candidate 1
cat eye syndrome chromosome region, candidate 1a
cat eye syndrome critical region protein 1 homolog A
NP_001028889.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033717.2NP_001028889.2  adenosine deaminase 2-A precursor

    See identical proteins and their annotated locations for NP_001028889.2

    Status: PROVISIONAL

    Source sequence(s)
    AF384217
    UniProtKB/Swiss-Prot
    P58781, Q7ZVJ3, Q8UVU4
    Related
    ENSDARP00000067907.5, ENSDART00000073416.6
    Conserved Domains (3) summary
    cd01321
    Location:75494
    ADGF; Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase.
    TIGR01431
    Location:30502
    adm_rel; adenosine deaminase-related growth factor
    pfam08451
    Location:2995
    A_deaminase_N; Adenosine/AMP deaminase N-terminal

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    16689638..16700924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)