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cpa capping protein alpha [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37387, updated on 28-Aug-2019

Summary

Official Symbol
cpaprovided by FlyBase
Official Full Name
capping protein alphaprovided by FlyBase
Primary source
FLYBASE:FBgn0034577
Locus tag
Dmel_CG10540
Gene type
protein coding
RNA name
capping protein alpha
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Cap1; CapZalpha; CG10540; Cpa; cpalpha; Dmel\CG10540; miro; scrd

Genomic context

See cpa in Genome Data Viewer
Location:
57B16-57B16; 2-92 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.26 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21057787..21059883)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16945292..16947388)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45148 Neighboring gene shotgun Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene Chitinase 8 Neighboring gene Chitinase 12

Genomic regions, transcripts, and products

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the cpa gene: The cpa gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
barbed-end actin filament capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
germarium-derived oocyte fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of JNK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
wing disc development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
F-actin capping protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
F-actin capping protein complex IDA
Inferred from Direct Assay
more info
PubMed 
WASH complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
actin cortical patch IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
capping protein alpha
Names
CG10540-PA
capping alpha
capping protein
capping protein A
capping proteinalpha
cpa-PA

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21057787..21059883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137695.4NP_611539.1  capping protein alpha [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611539.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W2N0
    Related
    FBpp0071461, FBtr0071532
    Conserved Domains (1) summary
    pfam01267
    Location:12282
    F-actin_cap_A; F-actin capping protein alpha subunit
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