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DND1 DND microRNA-mediated repression inhibitor 1 [ Homo sapiens (human) ]

Gene ID: 373863, updated on 23-Nov-2023

Summary

Official Symbol
DND1provided by HGNC
Official Full Name
DND microRNA-mediated repression inhibitor 1provided by HGNC
Primary source
HGNC:HGNC:23799
See related
Ensembl:ENSG00000256453 MIM:609385; AllianceGenome:HGNC:23799
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RBMS4
Summary
This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in testis (RPKM 7.3), colon (RPKM 6.1) and 25 other tissues See more
Orthologs
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Genomic context

See DND1 in Genome Data Viewer
Location:
5q31.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (140670794..140673576, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (141196191..141198973, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (140050379..140053161, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:140026953-140027488 Neighboring gene microRNA 3655 Neighboring gene IK cytokine Neighboring gene uncharacterized LOC124901088 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:140043900-140044566 Neighboring gene WD repeat domain 55 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:140052035-140052830 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:140052831-140053626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23284 Neighboring gene histidyl-tRNA synthetase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23285 Neighboring gene HARS1 and HARS2 bidirectional promoter region Neighboring gene histidyl-tRNA synthetase 2, mitochondrial

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC34750

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT enables miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in germ cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA stabilization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of miRNA-mediated gene silencing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of miRNA-mediated gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dead end protein homolog 1
Names
RNA-binding motif, single-stranded-interacting protein 4
dead end homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194249.3NP_919225.1  dead end protein homolog 1

    See identical proteins and their annotated locations for NP_919225.1

    Status: REVIEWED

    Source sequence(s)
    AC116353, BC033496
    Consensus CDS
    CCDS4236.1
    UniProtKB/Swiss-Prot
    Q8IYX4
    Related
    ENSP00000445366.1, ENST00000542735.2
    Conserved Domains (2) summary
    pfam14709
    Location:253333
    DND1_DSRM; double strand RNA binding domain from DEAD END PROTEIN 1
    cl25617
    Location:18219
    LSM_int_assoc; LSM-interacting associated unstructured

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    140670794..140673576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    141196191..141198973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)