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HILS1 histone linker H1 domain, spermatid-specific 1 (pseudogene) [ Homo sapiens (human) ]

Gene ID: 373861, updated on 17-Jun-2019

Summary

Official Symbol
HILS1provided by HGNC
Official Full Name
histone linker H1 domain, spermatid-specific 1 (pseudogene)provided by HGNC
Primary source
HGNC:HGNC:30616
See related
MIM:608101
Gene type
pseudo
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H1.9
Summary
This locus is the ortholog of a mouse protein-coding gene that displays characteristics of a linker histone and is expressed in nuclei of late maturing spermatids. The human locus is expressed; however, the open reading frame has been disrupted by a frameshift so it is unlikely to encode a functional protein. [provided by RefSeq, Oct 2008]
Expression
Biased expression in testis (RPKM 4.3), heart (RPKM 1.0) and 6 other tissues See more

Genomic context

See HILS1 in Genome Data Viewer
Location:
17q21.33
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (50171428..50172476, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (48248789..48249837, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5931 Neighboring gene uncharacterized LOC105371818 Neighboring gene Sharpr-MPRA regulatory region 13843 Neighboring gene sarcoglycan alpha Neighboring gene Sharpr-MPRA regulatory region 10059 Neighboring gene collagen type I alpha 1 chain

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Other Names

  • spermatid-specific linker histone H1-like protein

Gene Ontology Provided by GOA

Function Evidence Code Pubs
double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
nucleic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
chromatin remodeling NAS
Non-traceable Author Statement
more info
PubMed 
chromatin silencing IDA
Inferred from Direct Assay
more info
PubMed 
chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome condensation IDA
Inferred from Direct Assay
more info
PubMed 
germ cell development IDA
Inferred from Direct Assay
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of chromatin silencing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
nucleosome positioning IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spermatogenesis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear euchromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_024192.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal segment, compared to variant 1. Neither variant is likely to express a functional protein.
    Source sequence(s)
    AY286318, BC033456
  2. NR_024193.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Neither variant is likely to express a functional protein.
    Source sequence(s)
    AC015909, AY286318, BC033456, BC109047

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    50171428..50172476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_194072.1: Suppressed sequence

    Description
    NM_194072.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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