nog.L noggin L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: nog.L
Official Full Name: noggin L homeolog
Primary source: Xenbase:XB-GENE-864891
Locus tag: XELAEV_18043801mg
See related: AllianceGenome:Xenbase:XB-GENE-864891
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: nog; nog1; nog-A; Noggin1; noggin-1
Summary: Acts upstream of or within muscle organ development and negative regulation of BMP signaling pathway. Predicted to be located in extracellular region. Is expressed in several structures, including appendage; mesenchyme; nervous system; pharyngeal arch; and primary germ layer. Human ortholog(s) of this gene implicated in Huntington's disease; bone disease (multiple); cleft lip; and hyperopia. Orthologous to human NOG (noggin). [provided by Alliance of Genome Resources, Jul 2025]
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (32767307..32769128)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10L	NC_030740.1 (27175177..27176998)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

noggin 1, differently from noggin 2 and noggin 4, is expressed during all phases of Xenopus laevis retinal development. Gain-of-function experiments by electroporation in the optic vesicle show that overexpression of noggin 1 significantly decreases the number of bipolar cells in the inner nuclear layer of the retina, without significantly affecting the generation of the other retinal cell types.
Title: Noggin 1 overexpression in retinal progenitors affects bipolar cell generation.
a new role for Noggin1 in determining specific anterior neural structures by the modulation of TGFbeta and SHH signaling.
Title: Noggin-Mediated Retinal Induction Reveals a Novel Interplay Between Bone Morphogenetic Protein Inhibition, Transforming Growth Factor β, and Sonic Hedgehog Signaling.
The data provide a quantitative basis for modeling the process of Noggin1 diffusion in embryonic tissues, considering its interaction with heparan sulfate proteoglycans.
Title: Affinity of the heparin binding motif of Noggin1 to heparan sulfate and its visualization in the embryonic tissues.
This allow one to compare the expression levels of Noggin1 and Noggin 2 constructs, to purify them on the affine immunosorbent and to show the activity of Noggin proteins by analyzing their ability to bind BMP4 factor
Title: [The obtaining and analysis of physiological activity of secreted proteins of Noggin family].
Both Noggin proteins could induce a secondary head, including the forebrain. During normal development, Noggin1 mRNA was translated with low efficiency, providing sufficient Noggin1 only for antagonizing Bone morphogenetic protein.
Title: Novel functions of Noggin proteins: inhibition of Activin/Nodal and Wnt signaling.
Chordin, Noggin, beta-Catenin, and Cerberus have roles in neural induction in Xenopus
Title: Neural induction in Xenopus: requirement for ectodermal and endomesodermal signals via Chordin, Noggin, beta-Catenin, and Cerberus.
X-epilectin expression is down-regulated by Noggin and tBR and that this effect is inhibited by BMP4 over-expression, suggesting X-epilectin expression is mediated by the BMP signalling pathway
Title: X-epilectin: a novel epidermal fucolectin regulated by BMP signalling.
A 2066 bp noggin 5' flanking sequence which recapitulates the roof-plate expression of endogenous gene in transgenic frog tadpoles has been identified; this roof-plate enhancer has been mapped to a sequence as short as 79 bp.
Title: The Xenopus noggin promoter drives roof-plate specific transcription.
Noggin specifically blocks chondrogenic differentiation, rather than osteogenic differentiation, in mesodermal stem cell line C1 and skeletal cells.
Title: Noggin inhibits chondrogenic but not osteogenic differentiation in mesodermal stem cell line C1 and skeletal cells.
maternal mRNA encoding noggin is enriched in animal tiers and at low concentrations in the C-tier, suggesting that the neural fates of C-tier blastomeres may be responsive to early signaling from their neighboring cells
Title: Noggin signaling from Xenopus animal blastomere lineages promotes a neural fate in neighboring vegetal blastomere lineages.

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General gene information

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Gene Ontology Provided by Xenbase

Process	Evidence Code	Pubs
acts_upstream_of_or_within cartilage development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle organ development	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell differentiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: noggin

Names: noggin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.