Il18rap interleukin 18 receptor accessory protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il18rapprovided by RGD
Official Full Name: interleukin 18 receptor accessory proteinprovided by RGD
Primary source: RGD:727867
See related: Ensembl:ENSRNOG00000054218 AllianceGenome:RGD:727867
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable coreceptor activity and interleukin-18 receptor activity. Involved in cellular response to cytokine stimulus and cellular response to hydrogen peroxide. Predicted to be part of interleukin-18 receptor complex. Predicted to be active in cell surface and plasma membrane. Orthologous to human IL18RAP (interleukin 18 receptor accessory protein). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Spleen (RPKM 29.8), Lung (RPKM 13.6) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q22

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (50263723..50296583)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (42768112..42800964)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (47225543..47255805)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The aim of this study was to evaluate the constitutive expression of IL-18 and its receptors (IL-18Ralpha and IL-18Rbeta) in intestinal epithelial cells (IEC) stimulated by tumor necrosis factor-alpha and interferon-gamma.
Title: Constitutive expression of IL-18 and IL-18R in differentiated IEC-6 cells: effect of TNF-alpha and IFN-gamma treatment.
A novel splice variant of IL-18 receptor beta mRNA exists in rat brain; it encodes a putative truncated protein analogous to the soluble form of murine IL-1 receptor accessory protein and could act as an important regulator of IL-18 actions.
Title: Identification of a truncated IL-18R beta mRNA: a putative regulator of IL-18 expressed in rat brain.

Submit: New GeneRIF Correction

General gene information

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Markers

Il18rap (e-PCR), detects polymorphism
- UniSTS:525667

D9Rat63 (e-PCR)
- UniSTS:119191

AF077347 (e-PCR)
- UniSTS:163247

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables coreceptor activity	IEA Inferred from Electronic Annotation more info
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables interleukin-18 binding	TAS Traceable Author Statement more info	PubMed
enables interleukin-18 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-18 receptor activity	IEA Inferred from Electronic Annotation more info
enables interleukin-18 receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cytokine stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to interleukin-18	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to interleukin-18	ISO Inferred from Sequence Orthology more info
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-18-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within interleukin-18-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-18-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within interleukin-18-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-18-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutrophil activation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neutrophil activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
part_of interleukin-18 receptor complex	IEA Inferred from Electronic Annotation more info
part_of interleukin-18 receptor complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interleukin-18 receptor accessory protein

NP_908936.2

EC 3.2.2.6

XP_017452284.1

EC 3.2.2.6

XP_038940477.1

EC 3.2.2.6

XP_038940478.1

EC 3.2.2.6

XP_038940479.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_184047.2 → NP_908936.2 interleukin-18 receptor accessory protein precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A0G2K2K7, A6INP0

Related

ENSRNOP00000072281.1, ENSRNOT00000077303.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

50263723..50296583

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017596795.3 → XP_017452284.1 interleukin-18 receptor accessory protein isoform X1

UniProtKB/TrEMBL

A0A0G2K2K7, A6INP0

Conserved Domains (4) summary

pfam01582
Location:410 → 558

TIR; TIR domain

pfam18452
Location:101 → 154

Ig_6; Immunoglobulin domain

cd00096
Location:266 → 275

Ig; Ig strand B [structural motif]

cl11960
Location:263 → 353

Ig; Immunoglobulin domain
XM_039084549.2 → XP_038940477.1 interleukin-18 receptor accessory protein isoform X2

Conserved Domains (3) summary

pfam01582
Location:223 → 371

TIR; TIR domain

cd00096
Location:79 → 88

Ig; Ig strand B [structural motif]

cl11960
Location:76 → 166

Ig; Immunoglobulin domain
XM_039084551.2 → XP_038940479.1 interleukin-18 receptor accessory protein isoform X3

Conserved Domains (3) summary

pfam01582
Location:204 → 352

TIR; TIR domain

cd00096
Location:60 → 69

Ig; Ig strand B [structural motif]

cl11960
Location:57 → 147

Ig; Immunoglobulin domain
XM_039084550.2 → XP_038940478.1 interleukin-18 receptor accessory protein isoform X3

Conserved Domains (3) summary

pfam01582
Location:204 → 352

TIR; TIR domain

cd00096
Location:60 → 69

Ig; Ig strand B [structural motif]

cl11960
Location:57 → 147

Ig; Immunoglobulin domain