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Tcf/Lef HMG protein Tcf/Lef [ Strongylocentrotus purpuratus (purple sea urchin) ]

Gene ID: 373203, updated on 5-Sep-2025
Gene symbol
Tcf/Lef
Gene description
HMG protein Tcf/Lef
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Strongylocentrotus purpuratus
Lineage
Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea; Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae; Strongylocentrotus
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See Tcf/Lef in Genome Data Viewer
Location:
chromosome: Un
Exon count:
7
Annotation release Status Assembly Chr Location
102 current Spur_5.0 (GCF_000002235.5) Unplaced Scaffold NW_022145595.1 (16556749..16574496)
Build 3.1 previous assembly Spur_3.1 (GCF_000002235.3) Unplaced Scaffold NW_003577098.1 (50840..182907)

NW_022145595.1Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase TRIM71 Neighboring gene uncharacterized LOC105445413 Neighboring gene transcription factor 7-like 2 Neighboring gene ankyrin repeat domain-containing protein 17 Neighboring gene transfer RNA threonine (anticodon UGU)

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Involvement of Tcf/Lef in establishing cell types along the animal-vegetal axis of sea urchins. Huang L, et al. Dev Genes Evol, 2000 Feb. PMID 10664150
  2. Gene structure in the sea urchin Strongylocentrotus purpuratus based on transcriptome analysis. Tu Q, et al. Genome Res, 2012 Oct. PMID 22709795, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of beta-catenin-TCF complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
HMG protein Tcf/Lef

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214475.2 → NP_999640.1  HMG protein Tcf/Lef

    See identical proteins and their annotated locations for NP_999640.1

    Status: PROVISIONAL

    Source sequence(s)
    AF161594
    UniProtKB/TrEMBL
    Q9Y0B2
    Conserved Domains (2) summary
    cd01388
    Location:315 → 386
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1 → 219
    CTNNB1_binding; N-terminal CTNNB1 binding

RefSeqs of Annotated Genomes: Strongylocentrotus purpuratus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Spur_5.0 Primary Assembly

Genomic

  1. NW_022145595.1 Reference Spur_5.0 Primary Assembly

    Range
    16556749..16574496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030979630.1 → XP_030835490.1  HMG protein Tcf/Lef

    UniProtKB/TrEMBL
    A0A7M7NGM2
Nucleotide Protein
Heading Accession and Version

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