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pak1 p21 protein (Cdc42/Rac)-activated kinase 1 [ Danio rerio (zebrafish) ]

Gene ID: 373103, updated on 9-Sep-2025
Official Symbol
pak1provided by ZNC
Official Full Name
p21 protein (Cdc42/Rac)-activated kinase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030826-29
See related
Ensembl:ENSDARG00000103959 AllianceGenome:ZFIN:ZDB-GENE-030826-29
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb761; wu:fj97h10
Summary
Enables identical protein binding activity and protein kinase activity. Acts upstream of with a positive effect on canonical Wnt signaling pathway. Acts upstream of or within several processes, including bulbus arteriosus development; embryonic organ morphogenesis; and pro-T cell differentiation. Predicted to be active in cytoplasm. Is expressed in several structures, including axial mesoderm; cardiovascular system; nervous system; neural tube; and pectoral fin. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
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See pak1 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 18 NC_133193.1 (4128404..4221582, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 18 NC_007129.7 (3169897..3284188)

Chromosome 18 - NC_133193.1Genomic Context describing neighboring genes Neighboring gene calpain 5a Neighboring gene olfactory marker protein a Neighboring gene myosin VIIAa Neighboring gene glycerophosphodiester phosphodiesterase domain containing 4a Neighboring gene aquaporin 11 Neighboring gene chloride channel, nucleotide-sensitive, 1A

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development. Lightcap CM, et al. PLoS One, 2009 Jun 26. PMID 19557173, Free PMC Article
  2. A mutation in PAK3 with a dual molecular effect deregulates the RAS/MAPK pathway and drives an X-linked syndromic phenotype. Magini P, et al. Hum Mol Genet, 2014 Jul 1. PMID 24556213
  3. A betaPix Pak2a signaling pathway regulates cerebral vascular stability in zebrafish. Liu J, et al. Proc Natl Acad Sci U S A, 2007 Aug 28. PMID 17573532, Free PMC Article
  4. Pulses of RhoA signaling stimulate actin polymerization and flow in protrusions to drive collective cell migration. Qian W, et al. Curr Biol, 2024 Jan 22. PMID 38096821, Free PMC Article
  5. A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish. Kelly ML, et al. Dev Cell, 2014 May 12. PMID 24823378, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these data suggest an essential role for Pak1 as an Erk activator, and Gata6 as an Erk target, during neural crest development.
    Title: A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish.
  2. Two functional endothelial cell-specific miRNAs, miR-126a and miR-126b, synergistically regulate zebrafish vascular integrity, and pak1 is a critical target of miR-126a/b in vascular development.
    Title: Two functional microRNA-126s repress a novel target gene p21-activated kinase 1 to regulate vascular integrity in zebrafish.
  3. LC8 facilitates nuclear import of Pak1 and this function is indispensable during vertebrate development
    Title: Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bulbus arteriosus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within convergent extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pro-T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
serine/threonine-protein kinase PAK 1
Names
p21/Cdc42/Rac1-activated kinase 1
XP_021323273.1
XP_021323274.1
XP_068070833.1
XP_073785031.1
XP_073785032.1
XP_073785033.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201328.2 → NP_958485.2  serine/threonine-protein kinase PAK 1

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000018
    Related
    ENSDARP00000132462.2, ENSDART00000164724.2

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133193.1 Reference GRCz12tu Primary Assembly

    Range
    4128404..4221582 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073928932.1 → XP_073785033.1  serine/threonine-protein kinase PAK 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PFA6

  2. XM_073928930.1 → XP_073785031.1  serine/threonine-protein kinase PAK 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9P9X9

  3. XM_068214732.2 → XP_068070833.1  serine/threonine-protein kinase PAK 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PFA6

  4. XM_073928931.1 → XP_073785032.1  serine/threonine-protein kinase PAK 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9P9X9

  5. XM_021467599.3 → XP_021323274.1  serine/threonine-protein kinase PAK 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PFA6
    Related
    ENSDARP00000132912.2
    Conserved Domains (2) summary
    pfam00786
    Location:73 → 130
    PBD; P21-Rho-binding domain
    cl21453
    Location:283 → 578
    PKc_like; Protein Kinases, catalytic domain

  6. XM_021467598.3 → XP_021323273.1  serine/threonine-protein kinase PAK 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9P9X9
    Conserved Domains (2) summary
    pfam00786
    Location:73 → 130
    PBD; P21-Rho-binding domain
    cl21453
    Location:283 → 586
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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