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Ir56b Ionotropic receptor 56b [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37250, updated on 6-Jul-2026
Official Symbol
Ir56bprovided by FlyBase
Official Full Name
Ionotropic receptor 56bprovided by FlyBase
Primary source
FLYBASE:FBgn0034456
Locus tag
Dmel_CG15121
See related
AllianceGenome:FB:FBgn0034456
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
56b; CG15121; DmelIR56b; Dmel\CG15121; IR56b
Summary
Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in labellar taste bristle; leg taste bristle chemosensory neurons; proboscis; and tarsal segment. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See Ir56b in Genome Data Viewer
Location:
56D15-56D15; 2-89 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19508167..19509653)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15395672..15397158)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44472 Neighboring gene transfer RNA:Histidine-GTG 1-5 Neighboring gene Ionotropic receptor 56c Neighboring gene Ionotropic receptor 56d

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Modulation of attractive salt taste in Drosophila. McDowell SAT, et al. iScience, 2026 Mar 20. PMID 41852732, Free PMC Article
  2. Ir56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila. Dweck HKM, et al. Curr Biol, 2022 Apr 25. PMID 35294865, Free PMC Article
  3. Dietary salt induces taste desensitization via receptor internalization in Drosophila in a sexually dimorphic manner. Jin L, et al. Mol Cells, 2025 Aug. PMID 40541634, Free PMC Article
  4. New dimensions in the molecular genetics of insect chemoreception. Talross GJS, et al. Trends Genet, 2025 Aug. PMID 40340097, Free PMC Article
  5. Amino acids activate parallel chemosensory pathways in Drosophila. Guillemin J, et al. Chem Senses, 2025 Jan 22. PMID 40973625, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ligand-gated monoatomic ion channel activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in detection of chemical stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in detection of chemical stimulus involved in sensory perception IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
ionotropic receptor 56b
Names
CG15121-PB
CG15121-PC
Ir56b-PB
Ir56b-PC

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    19508167..19509653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001414062.1 → NP_001400982.1  ionotropic receptor 56b, isoform B

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBM7

  2. NM_001414063.1 → NP_001401019.1  ionotropic receptor 56b, isoform C

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0ACD4DAR4, E3CTQ7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZBM7 A1ZBM7

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