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hpo hippo [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37247, updated on 26-Aug-2021

Summary

Official Symbol
hpoprovided by FlyBase
Official Full Name
hippoprovided by FlyBase
Primary source
FLYBASE:FBgn0261456
Locus tag
Dmel_CG11228
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11228; Dmel\CG11228; dMST; hipo; Hippo; Hpo; HPO; MST; MST2
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Genomic context

See hpo in Genome Data Viewer
Location:
56D13-56D13; 2-89 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19493996..19496856, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15381501..15384361, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene par-1 Neighboring gene tubulin-binding cofactor B Neighboring gene Outer segment 6 Neighboring gene Rab escort protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in R8 cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hippo signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hippo signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in hippo signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hippo signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in morphogenesis of an epithelial sheet IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in organ growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein tetramerization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retinal cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stem cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in apicomedial cortex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
hippo
Names
CG11228-PA
CG11228-PB
HIPPO
MST
hippo kinase
hpo-PA
hpo-PB
NP_001261092.1
NP_611427.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    19493996..19496856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274163.1NP_001261092.1  hippo, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261092.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T0S6
    UniProtKB/TrEMBL
    A0A0B4KFW0
    Related
    FBpp0304253, FBtr0331920
    Conserved Domains (3) summary
    cd06612
    Location:38293
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:42293
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam11629
    Location:608655
    Mst1_SARAH; C terminal SARAH domain of Mst1
  2. NM_137583.5NP_611427.1  hippo, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611427.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T0S6
    UniProtKB/TrEMBL
    A0A0B4KFW0
    Related
    FBpp0085688, FBtr0086500
    Conserved Domains (3) summary
    cd06612
    Location:38293
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:42293
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam11629
    Location:608655
    Mst1_SARAH; C terminal SARAH domain of Mst1
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