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cer crammer [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37229, updated on 4-Apr-2024

Summary

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Official Symbol
cerprovided by FlyBase
Official Full Name
crammerprovided by FlyBase
Primary source
FLYBASE:FBgn0034443
Locus tag
Dmel_CG10460
See related
AllianceGenome:FB:FBgn0034443
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CER; CG10460; Crammer; D/CTLA-2; Dmel\CG10460
Summary
Enables cysteine-type endopeptidase inhibitor activity. Involved in inhibition of cysteine-type endopeptidase activity; long-term memory; and short-term memory. Located in endomembrane system. Is expressed in adult head; embryonic/larval garland cell; and prothoracic gland. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
56D3-56D3; 2-89 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19396215..19396772, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15283720..15284277, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45925 Neighboring gene Succinate dehydrogenase, subunit A (flavoprotein) Neighboring gene antisense RNA:CR43430 Neighboring gene hu li tai shao Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Studies of inhibitory mechanisms of propeptide-like cysteine protease inhibitors. Nga BT, et al. Enzyme Res, 2014. PMID 25045530, Free PMC Article
  2. Residue-specific annotation of disorder-to-order transition and cathepsin inhibition of a propeptide-like crammer from D. melanogaster. Tseng TS, et al. PLoS One, 2013. PMID 23349821, Free PMC Article
  3. Drosophila CTLA-2-like protein (D/CTLA-2) inhibits cysteine proteinase 1 (CP1), a cathepsin L-like enzyme. Deshapriya RM, et al. Zoolog Sci, 2007 Jan. PMID 17409713
  4. Short and long-lasting behavioral consequences of agonistic encounters between male Drosophila melanogaster. Trannoy S, et al. Proc Natl Acad Sci U S A, 2016 Apr 26. PMID 27071097, Free PMC Article
  5. To favor survival under food shortage, the brain disables costly memory. Plaçais PY, et al. Science, 2013 Jan 25. PMID 23349289

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Alanine substitution of residues W9, Y12, F16, Y20, Y32, and W53 within the hydrophobic cores, and charged residues E8, R28, R29, and E67 in the salt bridges considerably decrease the ability of crammer to inhibit cathepsin B (CTSB).
    Title: Residue-specific annotation of disorder-to-order transition and cathepsin inhibition of a propeptide-like crammer from D. melanogaster.
  2. first solution structure of propeptide-like protease inhibitor in its active form and examined in detail using a variety of spectroscopic methods the folding properties of crammer in order to delineate its biomolecular recognition of cathepsin
    Title: A molten globule-to-ordered structure transition of Drosophila melanogaster crammer is required for its ability to inhibit cathepsin.
  3. CTLA-2, implicated in intra- and extra-cellular digestive processes, functions by suppressing uncontrolled enzymatic activities of CP1.
    Title: Drosophila CTLA-2-like protein (D/CTLA-2) inhibits cysteine proteinase 1 (CP1), a cathepsin L-like enzyme.
  4. Cer might have a role in glia and the concentration of the Cer peptide is critical for long term memory
    Title: Drosophila long-term memory formation involves regulation of cathepsin activity.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in short-term memory IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
located_in lysosome ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
crammer
Names
CG10460-PA
CTLA-2-like protein
cer-PA
drosophila CTLA-2like protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    19396215..19396772 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137576.4 → NP_611420.1  crammer [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611420.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBK7
    Related
    FBpp0085735
    Conserved Domains (1) summary
    pfam08246
    Location:9 → 68
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZBK7 A1ZBK7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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