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MetRS Methionyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37177, updated on 4-Jan-2025

Summary

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Official Symbol
MetRSprovided by FlyBase
Official Full Name
Methionyl-tRNA synthetaseprovided by FlyBase
Primary source
FLYBASE:FBgn0034401
Locus tag
Dmel_CG15100
See related
AllianceGenome:FB:FBgn0034401
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Liang-2.15; CG15100; clone 2.15; Dmel\CG15100; dMetRS; MRS; p120
Summary
Predicted to enable methionine-tRNA ligase activity. Predicted to be involved in methionyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2U; hereditary spastic paraplegia 70; and trichothiodystrophy. Orthologous to human MARS1 (methionyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See MetRS in Genome Data Viewer
Location:
55F7-55F7; 2-86 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18846858..18850599, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14734363..14738104, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46485 Neighboring gene uncharacterized protein Neighboring gene Juvenile hormone epoxide hydrolase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases. Niehues S, et al. Nat Commun, 2015 Jul 3. PMID 26138142, Free PMC Article
  2. Cell-selective labelling of proteomes in Drosophila melanogaster. Erdmann I, et al. Nat Commun, 2015 Jul 3. PMID 26138272, Free PMC Article
  3. The Zinc-BED Transcription Factor Bedwarfed Promotes Proportional Dendritic Growth and Branching through Transcriptional and Translational Regulation in Drosophila. Bhattacharjee S, et al. Int J Mol Sci, 2023 Mar 28. PMID 37047316, Free PMC Article
  4. The multienzyme complex containing nine aminoacyl-tRNA synthetases is ubiquitous from Drosophila to mammals. Kerjan P, et al. Biochim Biophys Acta, 1994 Apr 21. PMID 8161568
  5. Methionyl-tRNA Synthetase Regulates Lifespan in Drosophila. Suh YS, et al. Mol Cells, 2020 Mar 31. PMID 31940717, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables methionine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methionine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables methionine-tRNA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables methionine-tRNA ligase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in methionyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in methionyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in methionyl-tRNA aminoacylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in methionyl-tRNA aminoacylation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of aminoacyl-tRNA synthetase multienzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Methionyl-tRNA synthetase
Names
CG15100-PA
MetRS-PA
NP_611382.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18846858..18850599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137538.2 → NP_611382.1  Methionyl-tRNA synthetase [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBE9, Q8MRS4
    Related
    FBpp0085809
    Conserved Domains (7) summary
    cd07957
    Location:634 → 763
    Anticodon_Ia_Met; Anticodon-binding domain of methionyl tRNA synthetases
    cd00814
    Location:255 → 625
    MetRS_core; catalytic core domain of methioninyl-tRNA synthetases
    COG0625
    Location:1 → 175
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    PRK12268
    Location:254 → 812
    PRK12268; methionyl-tRNA synthetase; Reviewed
    cd00570
    Location:1 → 65
    GST_N_family; Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic ...
    cd00939
    Location:895 → 938
    MetRS_RNA; MetRS_RNA binding domain. This short RNA-binding domain is found at the C-terminus of MetRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is repeated in Drosophila MetRS. This domain consists of a helix-turn-helix structure, which is ...
    cl02776
    Location:63 → 164
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZBE9 A1ZBE9
Q8MRS4 Q8MRS4

Gene LinkOut

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