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Gint3 GDI interacting protein 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37148, updated on 19-Nov-2025
Official Symbol
Gint3provided by FlyBase
Official Full Name
GDI interacting protein 3provided by FlyBase
Primary source
FLYBASE:FBgn0034372
Locus tag
Dmel_CG5469
See related
AllianceGenome:FB:FBgn0034372
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5469; Dmel\CG5469; Dromel_CG5469_FBtr0086654_gint3_mORF; UBX 6 like
Summary
Involved in positive regulation of canonical Wnt signaling pathway. Located in apical cortex. Is expressed in adult head; organism; and spermatozoon. Orthologous to human UBXN6 (UBX domain protein 6). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See Gint3 in Genome Data Viewer
Location:
55E5-55E5; 2-86 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18658418..18661548, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14545923..14549053, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Chemosensory protein A 56a Neighboring gene N-terminal amidohydrolase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ETS-domain lacking

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation. Beskow A, et al. J Mol Biol, 2009 Dec 11. PMID 19782090
  2. Genome-Wide Association Study on Male Genital Shape and Size in Drosophila melanogaster. Takahara B, et al. PLoS One, 2015. PMID 26182199, Free PMC Article
  3. Diversification of heart progenitor cells by EGF signaling and differential modulation of ETS protein activity. Schwarz B, et al. Elife, 2018 Jun 5. PMID 29869981, Free PMC Article
  4. Protection of armadillo/β-Catenin by armless, a novel positive regulator of wingless signaling. Reim G, et al. PLoS Biol, 2014 Nov. PMID 25369031, Free PMC Article
  5. Exhaustive identification of conserved upstream open reading frames with potential translational regulatory functions from animal genomes. Takahashi H, et al. Sci Rep, 2020 Oct 1. PMID 33004976, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
GDI interacting protein 3
Names
CG5469-PB
CG5469-PD
CG5469-PE
Gint3-PB
Gint3-PD
Gint3-PE

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18658418..18661548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137512.3 → NP_611356.1  GDI interacting protein 3, isoform D

    See identical proteins and their annotated locations for NP_611356.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K0S5
    Related
    FBpp0085836
    Conserved Domains (2) summary
    cd10460
    Location:171 → 268
    PUB_UBXD1; PNGase/UBA or UBX (PUB) domain of UBXD1
    cl00155
    Location:341 → 414
    UBQ; Ubiquitin-like proteins

  2. NM_166301.2 → NP_725812.1  GDI interacting protein 3, isoform B

    See identical proteins and their annotated locations for NP_725812.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K0S5
    Related
    FBpp0085837
    Conserved Domains (2) summary
    cd10460
    Location:171 → 268
    PUB_UBXD1; PNGase/UBA or UBX (PUB) domain of UBXD1
    cl00155
    Location:341 → 414
    UBQ; Ubiquitin-like proteins

  3. NM_166302.2 → NP_725813.1  GDI interacting protein 3, isoform E

    See identical proteins and their annotated locations for NP_725813.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K0S5
    Related
    FBpp0309338
    Conserved Domains (2) summary
    cd10460
    Location:171 → 268
    PUB_UBXD1; PNGase/UBA or UBX (PUB) domain of UBXD1
    cl00155
    Location:341 → 414
    UBQ; Ubiquitin-like proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K0S5 Q7K0S5

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