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IVL involucrin [ Homo sapiens (human) ]

Gene ID: 3713, updated on 9-Jun-2025
Official Symbol
IVLprovided by HGNC
Official Full Name
involucrinprovided by HGNC
Primary source
HGNC:HGNC:6187
See related
Ensembl:ENSG00000163207 MIM:147360; AllianceGenome:HGNC:6187
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward esophagus (RPKM 127.7) See more
Orthologs
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See IVL in Genome Data Viewer
Location:
1q21.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (152908546..152911886)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152045194..152048534)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152881022..152884362)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1736 Neighboring gene sperm mitochondria associated cysteine rich protein Neighboring gene IVL promoter region Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1336 Neighboring gene long intergenic non-protein coding RNA 1527 Neighboring gene small proline rich protein 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1738 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1739 Neighboring gene small proline rich protein 4

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine TAS
Traceable Author Statement
more info
PubMed 
involved_in keratinization IEA
Inferred from Electronic Annotation
more info
 
involved_in keratinocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptide cross-linking IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to UV-B IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 
located_in cornified envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in cornified envelope TAS
Traceable Author Statement
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
Preferred Names
involucrin

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033018.1 RefSeqGene

    Range
    4984..8324
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005547.4NP_005538.2  involucrin

    See identical proteins and their annotated locations for NP_005538.2

    Status: REVIEWED

    Source sequence(s)
    AK300492, AL162596, BC046391, DC387410
    Consensus CDS
    CCDS1030.1
    UniProtKB/Swiss-Prot
    P07476, Q5T7P4
    Related
    ENSP00000357753.3, ENST00000368764.4
    Conserved Domains (1) summary
    pfam10583
    Location:169
    Involucrin_N; Involucrin of squamous epithelia N-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    152908546..152911886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    152045194..152048534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)