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PIG-O Phosphatidylinositol glycan anchor biosynthesis class O [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37118, updated on 4-Jan-2025

Summary

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Official Symbol
PIG-Oprovided by FlyBase
Official Full Name
Phosphatidylinositol glycan anchor biosynthesis class Oprovided by FlyBase
Primary source
FLYBASE:FBgn0034346
Locus tag
Dmel_CG12263
See related
AllianceGenome:FB:FBgn0034346
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.205; CG12263; Dmel\CG12263; DmPIG-O; PIGO
Summary
Predicted to enable mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 2. Orthologous to human PIGO (phosphatidylinositol glycan anchor biosynthesis class O). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See PIG-O in Genome Data Viewer
Location:
55C9-55C9; 2-85 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18426421..18430333)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14313926..14317838)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene immune deficiency Neighboring gene Dodeca-satellite-binding protein 1 Neighboring gene uncharacterized protein Neighboring gene TRPL translocation defect 14 Neighboring gene scruin like at the midline Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Neighboring gene uncharacterized protein Neighboring gene Pre-RNA processing factor 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nuclear envelope localization of PIG-B is essential for GPI-anchor synthesis in Drosophila. Yamamoto-Hino M, et al. J Cell Sci, 2018 Oct 26. PMID 30266758, Free PMC Article
  2. Computational identification of Ftz/Ftz-F1 downstream target genes. Bowler T, et al. Dev Biol, 2006 Nov 1. PMID 16996052
  3. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
  4. GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors. Satoh T, et al. Development, 2013 Jan 15. PMID 23250212
  5. Large-language models facilitate discovery of the molecular signatures regulating sleep and activity. Peng D, et al. Nat Commun, 2024 May 1. PMID 38693116, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables mannose-ethanolamine phosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannose-ethanolamine phosphotransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidylinositol glycan anchor biosynthesis class O
Names
CG12263-PA
PIG-O-PA
NP_611332.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18426421..18430333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137488.3 → NP_611332.1  phosphatidylinositol glycan anchor biosynthesis class O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611332.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZB84, Q7YU86
    Related
    FBpp0085870
    Conserved Domains (1) summary
    cd16023
    Location:74 → 349
    GPI_EPT_3; GPI ethanolamine phosphate transferase 3, PIG-O
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZB84 A1ZB84
Q7YU86 Q7YU86

Gene LinkOut

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