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E1L poly(A) polymerase large subunit [ Vaccinia virus ]

Gene ID: 3707514, updated on 18-Aug-2023
Gene symbol
E1L
Gene description
poly(A) polymerase large subunit
Locus tag
VACWR057
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Vaccinia virus (strain: WR (Western Reserve))
Lineage
Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae; Orthopoxvirus
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Sequence:
NC_006998.1 (44004..45443, complement)

NC_006998.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene temporal expression: late Neighboring gene hypothetical protein Neighboring gene temporal expression: early Neighboring gene temporal expression: early

Genomic Sequence:
NC_006998.1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Domain-level rocking motion within a polymerase that translocates on single-stranded nucleic acid. Li H, et al. Acta Crystallogr D Biol Crystallogr, 2013 Apr. PMID 23519670, Free PMC Article
  2. Widespread but small-scale changes in the structural and dynamic properties of vaccinia virus poly(A) polymerase upon association with its processivity factor in solution. Li CZ, et al. Biochemistry, 2010 Jul 27. PMID 20469877
  3. Saltatory forward movement of a poly(A) polymerase during poly(A) tail addition. Yoshizawa JM, et al. J Biol Chem, 2007 Jun 29. PMID 17488726

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unliganded monomeric VP55 can undergo a ;rocking' motion of the N-terminal domain with respect to the other two domains, which may be ;rigidified' upon processivity factor (VP39) docking.
    Title: Domain-level rocking motion within a polymerase that translocates on single-stranded nucleic acid.
  2. Vaccinia virus poly(A) polymerase (VP55) has been analyzed via hydrogen-deuterium exchange mass spectrometry in the absence and presence of its processivity factor, VP39.
    Title: Widespread but small-scale changes in the structural and dynamic properties of vaccinia virus poly(A) polymerase upon association with its processivity factor in solution.
  3. there is for VP55 a discontinuous mode of translocation for a non-templated polymerase.
    Title: Saltatory forward movement of a poly(A) polymerase during poly(A) tail addition.
Submit: New GeneRIF Correction

Homology

Preferred Names
poly(A) polymerase large subunit
YP_232939.1
  • poly(A) polymerase large subunit; catalyses template-independent extension of the 3'-end of a DNA or RNA; The poxviridae are enveloped unsegmented dsDNA viruses; unlike many dsDNA viruses that replicate in the host nucleus poxviruses encode their own replication machinery and therefore replicate in the cytoplasm; viral genes are expressed in a bi-phasic manner with early genes encoding non-structural proteins involved in genome replication and late genes encoding the viral structural proteins

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_006998.1 Reference assembly

    Range
    44004..45443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_232939.1 poly-A polymerase catalytic subunit VP55 [Vaccinia virus]

    See identical proteins and their annotated locations for YP_232939.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P23371, Q6RZP5, Q80HX2
    UniProtKB/TrEMBL
    A0A2P1JPJ1, A9J1K2, L7QJ12
    Conserved Domains (1) summary
    PHA02996
    Location:13 → 479
    PHA02996; poly(A) polymerase large subunit; Provisional
Protein Accession Links
GenPept Link UniProtKB Link
AAO89336.1

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