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ITPKA inositol-trisphosphate 3-kinase A [ Homo sapiens (human) ]

Gene ID: 3706, updated on 20-Feb-2017
Official Symbol
ITPKAprovided by HGNC
Official Full Name
inositol-trisphosphate 3-kinase Aprovided by HGNC
Primary source
HGNC:HGNC:6178
See related
Ensembl:ENSG00000137825 MIM:147521; Vega:OTTHUMG00000130343
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IP3KA; IP3-3KA
Summary
Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]
Orthologs
Location:
15q15.1
Exon count:
8
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (41493858..41503559)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41786056..41795757)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 1 Neighboring gene RTF1 homolog, Paf1/RNA polymerase II complex component Neighboring gene uncharacterized LOC105370790 Neighboring gene leukocyte receptor tyrosine kinase Neighboring gene RNA polymerase II associated protein 1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of inositol-trisphosphate 3-kinase A (ITPKA) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Rac GTPase binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
inositol-1,4,5-trisphosphate 3-kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
dendritic spine maintenance IEA
Inferred from Electronic Annotation
more info
 
inositol metabolic process IEA
Inferred from Electronic Annotation
more info
 
inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
positive regulation of dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
inositol-trisphosphate 3-kinase A
Names
IP3 3-kinase A
IP3K A
inositol 1,4,5-trisphosphate 3-kinase A
insP 3-kinase A
NP_002211.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002220.2NP_002211.1  inositol-trisphosphate 3-kinase A

    See identical proteins and their annotated locations for NP_002211.1

    Status: REVIEWED

    Source sequence(s)
    AC087721, DB543073, X54938
    Consensus CDS
    CCDS10076.1
    UniProtKB/Swiss-Prot
    P23677
    Related
    ENSP00000260386, OTTHUMP00000160863, ENST00000260386, OTTHUMT00000252695
    Conserved Domains (1) summary
    pfam03770
    Location:245455
    IPK; Inositol polyphosphate kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

    Range
    41493858..41503559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521522.2XP_011519824.1  inositol-trisphosphate 3-kinase A isoform X1

    Conserved Domains (1) summary
    pfam03770
    Location:73283
    IPK; Inositol polyphosphate kinase

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    41904654..41914323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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