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STT3A STT3 oligosaccharyltransferase complex catalytic subunit A [ Homo sapiens (human) ]

Gene ID: 3703, updated on 5-Jul-2020

Summary

Official Symbol
STT3Aprovided by HGNC
Official Full Name
STT3 oligosaccharyltransferase complex catalytic subunit Aprovided by HGNC
Primary source
HGNC:HGNC:6172
See related
Ensembl:ENSG00000134910 MIM:601134
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMC; ITM1; STT3-A
Summary
The protein encoded by this gene is a catalytic subunit of the N-oligosaccharyltransferase (OST) complex, which functions in the endoplasmic reticulum to transfer glycan chains to asparagine residues of target proteins. A separate complex containing a similar catalytic subunit with an overlapping function also exists. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Expression
Ubiquitous expression in thyroid (RPKM 41.7), endometrium (RPKM 25.2) and 25 other tissues See more
Orthologs

Genomic context

See STT3A in Genome Data Viewer
Location:
11q24.2
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (125592847..125623091)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (125462690..125492654)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr11.5910 Neighboring gene STT3A antisense RNA 1 Neighboring gene RNA, U6 small nuclear 1156, pseudogene Neighboring gene EI24 autophagy associated transmembrane protein Neighboring gene checkpoint kinase 1 Neighboring gene RNA, U2 small nuclear 35, pseudogene Neighboring gene acrosomal vesicle protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Congenital disorder of glycosylation type 1w
MedGen: C3810062 OMIM: 615596 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study identifies five new schizophrenia loci.
NHGRI GWA Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of STT3, subunit of the oligosaccharyltransferase complex, homolog A (STT3A) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9042, FLJ27038

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dolichyl-diphosphooligosaccharide-protein glycotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dolichyl-diphosphooligosaccharide-protein glycotransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
dolichyl-diphosphooligosaccharide-protein glycotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
co-translational protein modification IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-translational protein modification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein N-linked glycosylation via asparagine IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein N-linked glycosylation via asparagine ISS
Inferred from Sequence or Structural Similarity
more info
 
protein N-linked glycosylation via asparagine TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
oligosaccharyltransferase III complex ISS
Inferred from Sequence or Structural Similarity
more info
 
oligosaccharyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
oligosaccharyltransferase complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
Names
B5
STT3, subunit of the oligosaccharyltransferase complex, homolog A
STT3A, catalytic subunit of the oligosaccharyltransferase complex
STT3A, cataylic subunit of the oligosaccharyltransferase complex
STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
dolichyl-diphosphooligosaccharide protein glycotransferase
integral membrane protein 1
integral transmembrane protein 1
oligosaccharyl transferase subunit STT3A
transmembrane conserved
transmembrane protein TMC
NP_001265432.1
NP_001265433.1
NP_689926.1
XP_011541109.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042806.1 RefSeqGene

    Range
    5058..35297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001278503.2NP_001265432.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A isoform a

    See identical proteins and their annotated locations for NP_001265432.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AP001132, AP001494, BC020965, BE503634, BM667548, BX649102, DA577274
    Consensus CDS
    CCDS8458.1
    UniProtKB/Swiss-Prot
    P46977
    Related
    ENSP00000436962.1, ENST00000529196.5
    Conserved Domains (1) summary
    pfam02516
    Location:17484
    STT3; Oligosaccharyl transferase STT3 subunit
  2. NM_001278504.2NP_001265433.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A isoform b

    See identical proteins and their annotated locations for NP_001265433.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks the exon containing the translation start codon compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (b) with a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK295892, AP001132, BC020965, BE503634, BM667548, DA577274
    Consensus CDS
    CCDS60998.1
    UniProtKB/Swiss-Prot
    P46977
    Related
    ENSP00000432820.1, ENST00000531491.5
    Conserved Domains (1) summary
    pfam02516
    Location:1392
    STT3; Oligosaccharyl transferase STT3 subunit
  3. NM_152713.5NP_689926.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A isoform a

    See identical proteins and their annotated locations for NP_689926.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AP001132, BC020965, BE503634, BM667548, DA577274
    Consensus CDS
    CCDS8458.1
    UniProtKB/Swiss-Prot
    P46977
    Related
    ENSP00000376472.3, ENST00000392708.9
    Conserved Domains (1) summary
    pfam02516
    Location:17484
    STT3; Oligosaccharyl transferase STT3 subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    125592847..125623091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542807.3XP_011541109.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A isoform X1

    See identical proteins and their annotated locations for XP_011541109.1

    UniProtKB/Swiss-Prot
    P46977
    Conserved Domains (1) summary
    pfam02516
    Location:17484
    STT3; Oligosaccharyl transferase STT3 subunit

RNA

  1. XR_001747860.2 RNA Sequence

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