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ITGB8 integrin subunit beta 8 [ Homo sapiens (human) ]

Gene ID: 3696, updated on 26-Apr-2020

Summary

Official Symbol
ITGB8provided by HGNC
Official Full Name
integrin subunit beta 8provided by HGNC
Primary source
HGNC:HGNC:6163
See related
Ensembl:ENSG00000105855 MIM:604160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Expression
Broad expression in kidney (RPKM 12.1), brain (RPKM 11.6) and 19 other tissues See more
Orthologs

Genomic context

See ITGB8 in Genome Data Viewer
Location:
7p21.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (20329819..20415754)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (20370345..20455382)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506098 Neighboring gene uncharacterized LOC101927769 Neighboring gene uncharacterized LOC101927811 Neighboring gene Sharpr-MPRA regulatory region 1382 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 27

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
extracellular matrix protein binding IDA
Inferred from Direct Assay
more info
PubMed 
integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
ganglioside metabolic process IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
placenta blood vessel development TAS
Traceable Author Statement
more info
PubMed 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transforming growth factor beta activation ISS
Inferred from Sequence or Structural Similarity
more info
 
vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin alphav-beta8 complex IDA
Inferred from Direct Assay
more info
PubMed 
integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin complex TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002214.3NP_002205.1  integrin beta-8 precursor

    See identical proteins and their annotated locations for NP_002205.1

    Status: REVIEWED

    Source sequence(s)
    AC004130, AW516961, BC002630, BI861225, M73780
    Consensus CDS
    CCDS5370.1
    UniProtKB/Swiss-Prot
    P26012
    UniProtKB/TrEMBL
    Q9BUG9
    Related
    ENSP00000222573.3, ENST00000222573.5
    Conserved Domains (1) summary
    smart00187
    Location:54469
    INB; Integrin beta subunits (N-terminal portion of extracellular region)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    20329819..20415754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515393.2XP_011513695.1  integrin beta-8 isoform X2

    Conserved Domains (1) summary
    smart00187
    Location:46461
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
  2. XM_017012179.1XP_016867668.1  integrin beta-8 isoform X1

    UniProtKB/Swiss-Prot
    P26012
    Conserved Domains (1) summary
    smart00187
    Location:54469
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
  3. XM_011515394.2XP_011513696.1  integrin beta-8 isoform X3

    Conserved Domains (1) summary
    smart00187
    Location:43458
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
  4. XM_017012183.1XP_016867672.1  integrin beta-8 isoform X4

    UniProtKB/Swiss-Prot
    P26012
    Conserved Domains (1) summary
    cl00057
    Location:1334
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  5. XM_017012180.1XP_016867669.1  integrin beta-8 isoform X4

    UniProtKB/Swiss-Prot
    P26012
    Conserved Domains (1) summary
    cl00057
    Location:1334
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  6. XM_017012181.1XP_016867670.1  integrin beta-8 isoform X4

    UniProtKB/Swiss-Prot
    P26012
    Conserved Domains (1) summary
    cl00057
    Location:1334
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  7. XM_011515396.1XP_011513698.1  integrin beta-8 isoform X4

    See identical proteins and their annotated locations for XP_011513698.1

    UniProtKB/Swiss-Prot
    P26012
    Related
    ENSP00000441561.1, ENST00000537992.5
    Conserved Domains (1) summary
    cl00057
    Location:1334
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  8. XM_017012178.1XP_016867667.1  integrin beta-8 isoform X1

    UniProtKB/Swiss-Prot
    P26012
    Conserved Domains (1) summary
    smart00187
    Location:54469
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
  9. XM_017012182.1XP_016867671.1  integrin beta-8 isoform X4

    UniProtKB/Swiss-Prot
    P26012
    Conserved Domains (1) summary
    cl00057
    Location:1334
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
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