Ldhal6b lactate dehydrogenase A-like 6B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ldhal6bprovided by RGD
Official Full Name: lactate dehydrogenase A-like 6Bprovided by RGD
Primary source: RGD:727955
See related: Ensembl:ENSRNOG00000062741 AllianceGenome:RGD:727955
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ldhl
Summary: Predicted to enable L-lactate dehydrogenase activity. Predicted to be involved in lactate metabolic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Orthologous to several human genes including LDHAL6B (lactate dehydrogenase A like 6B). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: human mouse all
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Genomic context

Location:: 1q11

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (48402997..48404420, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (45997845..45999268, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (46307853..46309276, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-lactate dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-lactate dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NAD+ metabolic process	IEA Inferred from Electronic Annotation more info
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lactate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lactate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lactate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in pyruvate catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: L-lactate dehydrogenase A-like 6B

NP_899163.1

EC 1.1.1.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183334.1 → NP_899163.1 L-lactate dehydrogenase A-like 6B

See identical proteins and their annotated locations for NP_899163.1

Status: PROVISIONAL

Source sequence(s)

AY342428

UniProtKB/TrEMBL

A0A8I6AFT6, Q7TNA8

Related

ENSRNOP00000093436.1, ENSRNOT00000102163.2

Conserved Domains (2) summary

cd05293
Location:70 → 379

LDH_1; A subgroup of L-lactate dehydrogenases

TIGR01771
Location:75 → 375

L-LDH-NAD; L-lactate dehydrogenase