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ITGB3 integrin subunit beta 3 [ Homo sapiens (human) ]

Gene ID: 3690, updated on 5-Jan-2022

Summary

Official Symbol
ITGB3provided by HGNC
Official Full Name
integrin subunit beta 3provided by HGNC
Primary source
HGNC:HGNC:6156
See related
Ensembl:ENSG00000259207 MIM:173470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GT; GT2; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16; BDPLT24
Summary
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
Expression
Broad expression in thyroid (RPKM 33.0), endometrium (RPKM 10.1) and 14 other tissues See more
Orthologs
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Genomic context

See ITGB3 in Genome Data Viewer
Location:
17q21.32
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (47253827..47313743)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (45331193..45391109)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr17.3215 Neighboring gene Sharpr-MPRA regulatory region 4457 Neighboring gene myosin light chain 4 Neighboring gene RNA, U7 small nuclear 186 pseudogene Neighboring gene uncharacterized LOC107985029 Neighboring gene Sharpr-MPRA regulatory region 4923 Neighboring gene Sharpr-MPRA regulatory region 4395 Neighboring gene VISTA enhancer hs2033 Neighboring gene EFCAB13 divergent transcript Neighboring gene EF-hand calcium binding domain 13 Neighboring gene UDP-N-acetylglucosamine pyrophosphorylase 1 pseudogene Neighboring gene nuclear factor, erythroid 2 like 3 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Bleeding disorder, platelet-type, 24
MedGen: CN296335 OMIM: 619271 GeneReviews: Not available
not available
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
GeneReviews: Not available
Glanzmann thrombasthenia 2
MedGen: CN296334 OMIM: 619267 GeneReviews: Not available
not available
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
GeneReviews: Not available
Myocardial infarction, susceptibility to
MedGen: C1832662 OMIM: 608446 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2012-08-27)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2012-08-27)

ClinGen Genome Curation Page

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 Tat complexes with gp120 to induce entry of VLPs expressing R5- or X4-tropic Env into MDDCs, which involves alpha5beta1, alpha5beta3, and alpha5beta5 integrins PubMed
Tat tat HIV-1 Tat-induced inhibition of IFN-gamma release is regulated by the interaction of Tat-RGD domain with alpha5beta1 and alpha5beta3 integrins in CD8+ T cells PubMed
tat HIV-1 Tat complexes with gp120 to induce entry of VLPs expressing R5- or X4-tropic Env into MDDCs, which involves alpha5beta1, alpha5beta3, and alpha5beta5 integrins PubMed
tat Endothelial cell adherent to HIV-1 Tat induces upregulation of VEGFR2, integrin beta(3) subunit, and pp60src and recruits VEGFR2, integrin beta(3) subunit, paxillin, focal adhesion kinase, and pp60src to ventral plasma membranes PubMed
tat Endothelial cell adherent to HIV-1 Tat induces rearrangement of actin cytoskeleton and is dependent on integrin alpha5beta3 PubMed
tat Sialic acid is required for signal transduction triggered by HIV-1 Tat/integrin alpha5beta3 interaction in endothelial cells PubMed
tat Sialic acid (NeuAc)-binding lectin from Maakia amurensis binds the NeuAc residues of integrin alpha5beta3 and inhibits the interaction of the integrin with the basic domain of HIV-1 Tat PubMed
tat HIV-1 Tat-induced platelet activation requires the chemokine receptor CCR3 and beta3-integrin expression on platelets and calcium flux in platelets PubMed
tat HIV-1 Tat-mediated inhibition of autophagy in bystander macrophages/monocytic cells requires CXCR4, VEGFR1, and beta-integrins PubMed
tat The arginine-glycine-aspartic acid (RGD) sequence present at the carboxy-terminal of HIV-1 Tat mediates vascular cell and monocyte migration and invasion by binding to the alpha-5-beta-1 and alpha-v-beta-3 integrins PubMed
tat HIV-1 Tat induced monocyte invasion is inhibited by anti-beta integrin Ab or tissue inhibitor of metalloproteinase (TIMP), indicating an interaction with beta integrins and TIMP PubMed
tat HIV-1 Tat upregulates the levels of CD61 in phorbol myristate acetate (PMA)-stimulated K562 hematopoietic progenitor cells PubMed
tat HIV-1 Tat exerts several pleiotropic effects by interacting with different cellular receptors, including integrin alpha(v)beta3, which triggers the activation of focal adhesion kinase, RhoA and pp60src PubMed
tat IFN-gamma interacts with HIV-1 Tat to induce endothelial cells to proliferate and invade the extracellular matrix by upregulating the receptors for Tat (integrins alpha-5-beta-1 and alpha-v-beta-3), suggesting Tat and IFN-gamma play major roles in AIDS-KS PubMed
tat The RGD-containing domain of exogenous HIV-1 Tat inhibits the engulfment of apoptotic bodies by dendritic cells through an interaction with integrin alpha v beta 3 PubMed
tat HIV-1 Tat induces angiogenesis and cooperates in the development of AIDS-associated Kaposi sarcoma as a result of interactions with integrins alpha-5-beta-1 and alpha-v-beta 3 PubMed
nucleocapsid gag HIV-1 NC upregulates integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to C-X3-C chemokine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables coreceptor activity TAS
Traceable Author Statement
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables extracellular matrix binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to fibrinogen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to fibroblast growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables fibronectin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fibronectin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to insulin-like growth factor I binding IDA
Inferred from Direct Assay
more info
PubMed 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to neuregulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables platelet-derived growth factor receptor binding TAS
Traceable Author Statement
more info
PubMed 
enables protease binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein disulfide isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables vascular endothelial growth factor receptor 2 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables vascular endothelial growth factor receptor 2 binding TAS
Traceable Author Statement
more info
PubMed 
enables virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in activation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiogenesis involved in wound healing TAS
Traceable Author Statement
more info
PubMed 
involved_in apolipoprotein A-I-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic cell clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in blood coagulation TAS
Traceable Author Statement
more info
PubMed 
involved_in cell adhesion TAS
Traceable Author Statement
more info
PubMed 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell adhesion mediated by integrin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in integrin-mediated signaling pathway HDA PubMed 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in integrin-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in mesodermal cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of lipid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of lipoprotein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of low-density lipoprotein receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of macrophage derived foam cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in platelet activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of bone resorption TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization EXP
Inferred from Experiment
more info
PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of serotonin uptake ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tube development TAS
Traceable Author Statement
more info
PubMed 
involved_in viral entry into host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wound healing IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
part_of alphav-beta3 integrin-HMGB1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of alphav-beta3 integrin-IGF-1-IGF1R complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of alphav-beta3 integrin-PKCalpha complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of alphav-beta3 integrin-vitronectin complex TAS
Traceable Author Statement
more info
PubMed 
located_in cell surface HDA PubMed 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in filopodium membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in focal adhesion HDA PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
part_of integrin alphav-beta3 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of integrin complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in melanosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in microvillus membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in platelet alpha granule membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
integrin beta-3
Names
antigen CD61
integrin beta 3
integrin beta chain, beta 3
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
platelet membrane glycoprotein IIIa

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008332.2 RefSeqGene

    Range
    5001..63870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_481

mRNA and Protein(s)

  1. NM_000212.3NP_000203.2  integrin beta-3 precursor

    See identical proteins and their annotated locations for NP_000203.2

    Status: REVIEWED

    Source sequence(s)
    AC068234, M35999
    Consensus CDS
    CCDS11511.1
    UniProtKB/Swiss-Prot
    P05106
    Related
    ENSP00000452786.2, ENST00000559488.7
    Conserved Domains (3) summary
    pfam00362
    Location:38461
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:634717
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:744786
    Integrin_b_cyt; Integrin beta cytoplasmic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    47253827..47313743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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