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ITGB3 integrin subunit beta 3 [ Homo sapiens (human) ]

Gene ID: 3690, updated on 29-Mar-2020

Summary

Official Symbol
ITGB3provided by HGNC
Official Full Name
integrin subunit beta 3provided by HGNC
Primary source
HGNC:HGNC:6156
See related
Ensembl:ENSG00000259207 MIM:173470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16
Summary
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
Expression
Broad expression in thyroid (RPKM 33.0), endometrium (RPKM 10.1) and 14 other tissues See more
Orthologs

Genomic context

See ITGB3 in Genome Data Viewer
Location:
17q21.32
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (47253827..47313743)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (45331208..45390077)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr17.3215 Neighboring gene myosin light chain 4 Neighboring gene RNA, U7 small nuclear 186 pseudogene Neighboring gene uncharacterized LOC107985029 Neighboring gene Sharpr-MPRA regulatory region 4395 Neighboring gene VISTA enhancer hs2033 Neighboring gene thyroid cancer-associated transcript 158 Neighboring gene EF-hand calcium binding domain 13 Neighboring gene UDP-N-acetylglucosamine pyrophosphorylase 1 pseudogene Neighboring gene nuclear factor, erythroid 2 like 3 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Glanzmann thrombasthenia
MedGen: C0040015 OMIM: 273800 GeneReviews: Not available
Compare labs
Myocardial infarction 1
MedGen: C1832662 OMIM: 608446 GeneReviews: Not available
Compare labs
Platelet-type bleeding disorder 16
MedGen: C1861195 OMIM: 187800 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2012-08-27)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2012-08-27)

ClinGen Genome Curation Page

NHGRI GWAS Catalog

Description
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 Tat complexes with gp120 to induce entry of VLPs expressing R5- or X4-tropic Env into MDDCs, which involves alpha5beta1, alpha5beta3, and alpha5beta5 integrins PubMed
Tat tat HIV-1 Tat-induced inhibition of IFN-gamma release is regulated by the interaction of Tat-RGD domain with alpha5beta1 and alpha5beta3 integrins in CD8+ T cells PubMed
tat HIV-1 Tat complexes with gp120 to induce entry of VLPs expressing R5- or X4-tropic Env into MDDCs, which involves alpha5beta1, alpha5beta3, and alpha5beta5 integrins PubMed
tat Endothelial cell adherent to HIV-1 Tat induces upregulation of VEGFR2, integrin beta(3) subunit, and pp60src and recruits VEGFR2, integrin beta(3) subunit, paxillin, focal adhesion kinase, and pp60src to ventral plasma membranes PubMed
tat Endothelial cell adherent to HIV-1 Tat induces rearrangement of actin cytoskeleton and is dependent on integrin alpha5beta3 PubMed
tat Sialic acid is required for signal transduction triggered by HIV-1 Tat/integrin alpha5beta3 interaction in endothelial cells PubMed
tat Sialic acid (NeuAc)-binding lectin from Maakia amurensis binds the NeuAc residues of integrin alpha5beta3 and inhibits the interaction of the integrin with the basic domain of HIV-1 Tat PubMed
tat HIV-1 Tat-induced platelet activation requires the chemokine receptor CCR3 and beta3-integrin expression on platelets and calcium flux in platelets PubMed
tat HIV-1 Tat-mediated inhibition of autophagy in bystander macrophages/monocytic cells requires CXCR4, VEGFR1, and beta-integrins PubMed
tat The arginine-glycine-aspartic acid (RGD) sequence present at the carboxy-terminal of HIV-1 Tat mediates vascular cell and monocyte migration and invasion by binding to the alpha-5-beta-1 and alpha-v-beta-3 integrins PubMed
tat HIV-1 Tat induced monocyte invasion is inhibited by anti-beta integrin Ab or tissue inhibitor of metalloproteinase (TIMP), indicating an interaction with beta integrins and TIMP PubMed
tat HIV-1 Tat upregulates the levels of CD61 in phorbol myristate acetate (PMA)-stimulated K562 hematopoietic progenitor cells PubMed
tat HIV-1 Tat exerts several pleiotropic effects by interacting with different cellular receptors, including integrin alpha(v)beta3, which triggers the activation of focal adhesion kinase, RhoA and pp60src PubMed
tat IFN-gamma interacts with HIV-1 Tat to induce endothelial cells to proliferate and invade the extracellular matrix by upregulating the receptors for Tat (integrins alpha-5-beta-1 and alpha-v-beta-3), suggesting Tat and IFN-gamma play major roles in AIDS-KS PubMed
tat The RGD-containing domain of exogenous HIV-1 Tat inhibits the engulfment of apoptotic bodies by dendritic cells through an interaction with integrin alpha v beta 3 PubMed
tat HIV-1 Tat induces angiogenesis and cooperates in the development of AIDS-associated Kaposi sarcoma as a result of interactions with integrins alpha-5-beta-1 and alpha-v-beta 3 PubMed
nucleocapsid gag HIV-1 NC upregulates integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to C-X3-C chemokine binding IDA
Inferred from Direct Assay
more info
PubMed 
cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
coreceptor activity TAS
Traceable Author Statement
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
extracellular matrix binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to fibrinogen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to fibroblast growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
fibronectin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibronectin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to insulin-like growth factor I binding IDA
Inferred from Direct Assay
more info
PubMed 
integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to neuregulin binding IDA
Inferred from Direct Assay
more info
PubMed 
platelet-derived growth factor receptor binding TAS
Traceable Author Statement
more info
PubMed 
protease binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein disulfide isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
vascular endothelial growth factor receptor 2 binding IPI
Inferred from Physical Interaction
more info
PubMed 
vascular endothelial growth factor receptor 2 binding TAS
Traceable Author Statement
more info
PubMed 
virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis involved in wound healing TAS
Traceable Author Statement
more info
PubMed 
apolipoprotein A-I-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic cell clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
blood coagulation TAS
Traceable Author Statement
more info
PubMed 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell adhesion mediated by integrin IDA
Inferred from Direct Assay
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin-mediated signaling pathway HDA PubMed 
integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
mesodermal cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
negative chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of lipid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of lipoprotein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of low-density lipoprotein particle receptor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of macrophage derived foam cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
platelet activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
regulation of bone resorption TAS
Traceable Author Statement
more info
PubMed 
regulation of postsynaptic neurotransmitter receptor internalization EXP
Inferred from Experiment
more info
PubMed 
regulation of postsynaptic neurotransmitter receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of postsynaptic neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of serotonin uptake ISS
Inferred from Sequence or Structural Similarity
more info
 
smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
tube development TAS
Traceable Author Statement
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
viral entry into host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
wound healing IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
alphav-beta3 integrin-HMGB1 complex IDA
Inferred from Direct Assay
more info
PubMed 
alphav-beta3 integrin-IGF-1-IGF1R complex IDA
Inferred from Direct Assay
more info
PubMed 
alphav-beta3 integrin-PKCalpha complex IDA
Inferred from Direct Assay
more info
PubMed 
alphav-beta3 integrin-vitronectin complex TAS
Traceable Author Statement
more info
PubMed 
cell surface HDA PubMed 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
filopodium membrane IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion HDA PubMed 
focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
integrin alphav-beta3 complex IDA
Inferred from Direct Assay
more info
PubMed 
integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin complex IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium membrane IDA
Inferred from Direct Assay
more info
PubMed 
melanosome IDA
Inferred from Direct Assay
more info
PubMed 
microvillus membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
platelet alpha granule membrane TAS
Traceable Author Statement
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 
synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
integrin beta-3
Names
antigen CD61
integrin beta 3
integrin beta chain, beta 3
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
platelet membrane glycoprotein IIIa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008332.2 RefSeqGene

    Range
    5001..63870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_481

mRNA and Protein(s)

  1. NM_000212.3NP_000203.2  integrin beta-3 precursor

    See identical proteins and their annotated locations for NP_000203.2

    Status: REVIEWED

    Source sequence(s)
    AC068234, M35999
    Consensus CDS
    CCDS11511.1
    UniProtKB/Swiss-Prot
    P05106
    Related
    ENSP00000452786.1, ENST00000559488.6
    Conserved Domains (3) summary
    pfam00362
    Location:38461
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:634717
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:744786
    Integrin_b_cyt; Integrin beta cytoplasmic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    47253827..47313743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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