Format

Send to:

Choose Destination

Sod2 Superoxide dismutase 2 (Mn) [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36878, updated on 9-Oct-2018

Summary

Official Symbol
Sod2provided by FlyBase
Official Full Name
Superoxide dismutase 2 (Mn)provided by FlyBase
Primary source
FLYBASE:FBgn0010213
Locus tag
Dmel_CG8905
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8905; Dmel\CG8905; dSod2; dSOD2; Mito SOD; mitSOD2; Mn SOD; Mn-SOD; Mn-SOD2; mnSOD; MnSOD; MnSODII; Mn[2+]SOD; SOD; Sod-2; SOD-2; sod2; SOD2

Genomic context

See Sod2 in Genome Data Viewer
Location:
53D8-53D8; 2-80 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16772785..16773915, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12660290..12661420, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncoordinated-104 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Actin-related protein 53D Neighboring gene Vitamin-K epoxide reductase

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Detoxification of Reactive Oxygen Species, organism-specific biosystem (from REACTOME)
    Detoxification of Reactive Oxygen Species, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • Longevity regulating pathway - multiple species, organism-specific biosystem (from KEGG)
    Longevity regulating pathway - multiple species, organism-specific biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
  • Longevity regulating pathway - multiple species, conserved biosystem (from KEGG)
    Longevity regulating pathway - multiple species, conserved biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
  • MAPK signaling pathway - fly, organism-specific biosystem (from KEGG)
    MAPK signaling pathway - fly, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) signaling cascades that are highly conserved from yeast to mammals use protein phosphorylation to convey signals intracellularly, and play a crucial role i...
  • MAPK signaling pathway - fly, conserved biosystem (from KEGG)
    MAPK signaling pathway - fly, conserved biosystemThe mitogen-activated protein kinase (MAPK) signaling cascades that are highly conserved from yeast to mammals use protein phosphorylation to convey signals intracellularly, and play a crucial role i...
  • Peroxisome, organism-specific biosystem (from KEGG)
    Peroxisome, organism-specific biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
  • Peroxisome, conserved biosystem (from KEGG)
    Peroxisome, conserved biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the Sod2 gene: The Sod2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
antioxidant activity NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
superoxide dismutase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
superoxide dismutase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
aging IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
determination of adult lifespan TAS
Traceable Author Statement
more info
PubMed 
heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
paracrine signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of autophagy of mitochondrion IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of hemocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
removal of superoxide radicals ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
superoxide dismutase 2 (Mn)
Names
CG8905-PA
CG8905-PB
Mn superoxide dismutase
Mn-superoxide dismutase
MnSOD
Sod2-PA
Sod2-PB
manganese superoxide dismutase
manganese-SOD
mitochodnrial SOD
mitochondrial Mn-superoxide dismutase 2
mitochondrial MnSOD
mitochondrial superoxide dismutase 2
superoxide dismutase
superoxide dismutase 2
superoxide dismutase-2
superoxide dismutatase 2
NP_001286503.1
NP_476925.1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16772785..16773915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299574.1NP_001286503.1  superoxide dismutase 2 (Mn), isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286503.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q00637
    UniProtKB/TrEMBL
    A0A0B4LGQ1
    Related
    FBpp0311603, FBtr0345492
    Conserved Domains (3) summary
    COG0605
    Location:16214
    SodA; Superoxide dismutase [Inorganic ion transport and metabolism]
    pfam00081
    Location:1899
    Sod_Fe_N; Iron/manganese superoxide dismutases, alpha-hairpin domain
    pfam02777
    Location:105208
    Sod_Fe_C; Iron/manganese superoxide dismutases, C-terminal domain
  2. NM_057577.4NP_476925.1  superoxide dismutase 2 (Mn), isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476925.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q00637
    UniProtKB/TrEMBL
    A0A0B4LGQ1
    Related
    FBpp0086226, FBtr0087078
    Conserved Domains (3) summary
    COG0605
    Location:16214
    SodA; Superoxide dismutase [Inorganic ion transport and metabolism]
    pfam00081
    Location:1899
    Sod_Fe_N; Iron/manganese superoxide dismutases, alpha-hairpin domain
    pfam02777
    Location:105208
    Sod_Fe_C; Iron/manganese superoxide dismutases, C-terminal domain
Support Center