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abcc4 ATP binding cassette subfamily C member 4 (PEL blood group) [ Danio rerio (zebrafish) ]

Gene ID: 368620, updated on 2-Nov-2024

Summary

Official Symbol
abcc4provided by ZNC
Official Full Name
ATP binding cassette subfamily C member 4 (PEL blood group)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030616-511
See related
Ensembl:ENSDARG00000058953 AllianceGenome:ZFIN:ZDB-GENE-030616-511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
MRP; lkt; cb1019; sb:eu668; sb:eu872; dZ52I16.4; si:dz52i16.4; si:dz202l16.5; si:busm1-52i16.4
Summary
Enables ABC-type transporter activity; efflux transmembrane transporter activity; and prostaglandin transmembrane transporter activity. Acts upstream of or within detoxification of inorganic compound; prostaglandin secretion; and regulation of cilium assembly. Located in plasma membrane. Is expressed in several structures, including Kupffer's vesicle; digestive system; musculature system; nervous system; and pleuroperitoneal region. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See abcc4 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (7322449..7391805)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (7165535..7234620)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene claudin 10e Neighboring gene claudin 10a Neighboring gene coiled-coil domain containing 65 Neighboring gene SRY-box transcription factor 21a Neighboring gene FKBP prolyl isomerase 11

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ABC-type transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATPase-coupled transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
 
enables efflux transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables intracellularly ATP-gated chloride channel activity IEA
Inferred from Electronic Annotation
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables prostaglandin transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ATP-binding cassette sub-family C member 4
Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
leakytail
multidrug resistance-associated protein member 4
NP_001007039.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007038.2NP_001007039.2  ATP-binding cassette sub-family C member 4

    Status: VALIDATED

    Source sequence(s)
    AL953886, BX663606
    UniProtKB/TrEMBL
    Q8QFL6
    Related
    ENSDARP00000065499.4, ENSDART00000065500.5
    Conserved Domains (1) summary
    cl26602
    Location:111289
    SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    7322449..7391805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394625.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    107500..176639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)