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ITGAV integrin subunit alpha V [ Homo sapiens (human) ]

Gene ID: 3685, updated on 16-Feb-2020

Summary

Official Symbol
ITGAVprovided by HGNC
Official Full Name
integrin subunit alpha Vprovided by HGNC
Primary source
HGNC:HGNC:6150
See related
Ensembl:ENSG00000138448 MIM:193210
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD51; MSK8; VNRA; VTNR
Summary
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
Expression
Ubiquitous expression in thyroid (RPKM 45.9), ovary (RPKM 36.3) and 24 other tissues See more
Orthologs

Genomic context

See ITGAV in Genome Data Viewer
Location:
2q32.1
Exon count:
31
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (186590056..186680902)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (187454058..187545629)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing 15 Neighboring gene divergent-paired related homeobox pseudogene 1 Neighboring gene uncharacterized LOC107985784 Neighboring gene family with sequence similarity 171 member B Neighboring gene zinc finger SWIM-type containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 Tat complexes with gp120 to induce entry of VLPs expressing R5- or X4-tropic Env into MDDCs, which involves alpha5beta1, alpha5beta3, and alpha5beta5 integrins PubMed
env HIV-1 gp120 interacts with CD4 and alphavbeta3 in peripheral blood monocyte-derived macrophages; neutralizing antibodies against the alphavbeta3 integrin interfere with the coprecipitation of alphavbeta3 with an anti-gp120 antibody PubMed
Tat tat HIV-1 Tat complexes with gp120 to induce entry of VLPs expressing R5- or X4-tropic Env into MDDCs, which involves alpha5beta1, alpha5beta3, and alpha5beta5 integrins PubMed
tat Endothelial cell adherent to HIV-1 Tat induces rearrangement of actin cytoskeleton and is dependent on integrin alpha5beta3 PubMed
tat Sialic acid is required for signal transduction triggered by HIV-1 Tat/integrin alpha5beta3 interaction in endothelial cells PubMed
tat Sialic acid (NeuAc)-binding lectin from Maakia amurensis binds the NeuAc residues of integrin alpha5beta3 and inhibits the interaction of the integrin with the basic domain of HIV-1 Tat PubMed
tat HIV-1 Tat exerts several pleiotropic effects by interacting with different cellular receptors, including integrin alpha(v)beta3, which triggers the activation of focal adhesion kinase, RhoA and pp60src PubMed
tat IFN-gamma interacts with HIV-1 Tat to induce endothelial cells to proliferate and invade the extracellular matrix by upregulating the receptors for Tat (integrins alpha-5-beta-1 and alpha-v-beta-3), suggesting Tat and IFN-gamma play major roles in AIDS-KS PubMed
tat The arginine-glycine-aspartic acid (RGD) sequence present at the carboxy-terminal of HIV-1 Tat mediates vascular cell and monocyte migration and invasion by binding to the alpha-5-beta-1 and alpha-v-beta-3 integrins PubMed
tat The RGD-containing domain of exogenous HIV-1 Tat inhibits the engulfment of apoptotic bodies by dendritic cells through an interaction with integrin alpha v beta 3 PubMed
tat HIV-1 Tat induces angiogenesis and cooperates in the development of AIDS-associated Kaposi sarcoma as a result of interactions with integrins alpha-5-beta-1 and alpha-v-beta 3 PubMed
tat Interaction of HIV-1 Tat with alpha 5, beta 1, and alpha v subunits of surface integrin receptors mediates activation of CD4+ T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686A08142

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to C-X3-C chemokine binding IDA
Inferred from Direct Assay
more info
PubMed 
coreceptor activity TAS
Traceable Author Statement
more info
PubMed 
extracellular matrix binding IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix protein binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to fibroblast growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
fibronectin binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to insulin-like growth factor I binding IDA
Inferred from Direct Assay
more info
PubMed 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to neuregulin binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to opsonin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protease binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to protein kinase C binding ISS
Inferred from Sequence or Structural Similarity
more info
 
transforming growth factor beta binding ISS
Inferred from Sequence or Structural Similarity
more info
 
virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
angiogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
Traceable Author Statement
more info
 
apolipoprotein A-I-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic cell clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
apoptotic cell clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
cell adhesion mediated by integrin IDA
Inferred from Direct Assay
more info
PubMed 
cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-matrix adhesion NAS
Non-traceable Author Statement
more info
PubMed 
cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
endodermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
entry of symbiont into host cell by promotion of host phagocytosis NAS
Non-traceable Author Statement
more info
PubMed 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
extrinsic apoptotic signaling pathway in absence of ligand ISS
Inferred from Sequence or Structural Similarity
more info
 
heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
negative chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of entry of bacterium into host cell IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of lipid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of lipoprotein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of low-density lipoprotein particle receptor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of macrophage derived foam cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoblast proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transforming growth factor beta activation IDA
Inferred from Direct Assay
more info
PubMed 
substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
transforming growth factor-beta secretion IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
viral entry into host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral entry into host cell TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
alphav-beta3 integrin-HMGB1 complex IDA
Inferred from Direct Assay
more info
PubMed 
alphav-beta3 integrin-IGF-1-IGF1R complex IDA
Inferred from Direct Assay
more info
PubMed 
alphav-beta3 integrin-PKCalpha complex NAS
Non-traceable Author Statement
more info
PubMed 
cell IEA
Inferred from Electronic Annotation
more info
 
cell surface HDA PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
filopodium membrane IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion HDA PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
integrin alphav-beta3 complex IDA
Inferred from Direct Assay
more info
PubMed 
integrin alphav-beta5 complex IDA
Inferred from Direct Assay
more info
PubMed 
integrin alphav-beta6 complex IDA
Inferred from Direct Assay
more info
PubMed 
integrin alphav-beta8 complex IDA
Inferred from Direct Assay
more info
PubMed 
integrin complex IDA
Inferred from Direct Assay
more info
PubMed 
integrin complex NAS
Non-traceable Author Statement
more info
PubMed 
lamellipodium membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
microvillus membrane IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle TAS
Traceable Author Statement
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 
specific granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
integrin alpha-V
Names
antigen identified by monoclonal antibody L230
integrin alphaVbeta3
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
vitronectin receptor subunit alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144999.2NP_001138471.1  integrin alpha-V isoform 2 precursor

    See identical proteins and their annotated locations for NP_001138471.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct and shorter N-terminus, compared to isoform 1. It is not known whether this isoform (2) is proteolytically processed in the same manner as isoform 1.
    Source sequence(s)
    AK302990, BC047454, BQ101180, CB962576, CN409399, DA736912
    Consensus CDS
    CCDS46471.1
    UniProtKB/Swiss-Prot
    P06756
    Related
    ENSP00000404291.2, ENST00000433736.6
    Conserved Domains (4) summary
    smart00191
    Location:321375
    Int_alpha; Integrin alpha (beta-propellor repeats)
    sd00039
    Location:80137
    7WD40; WD40 repeat [structural motif]
    pfam08441
    Location:421868
    Integrin_alpha2; Integrin alpha
    pfam13517
    Location:175225
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
  2. NM_001145000.3NP_001138472.2  integrin alpha-V isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the coding region compared to variant 1. This results in a shorter protein (isoform 3) compared to isoform 1. It is not known whether this isoform (3) is proteolytically processed in the same manner as isoform 1.
    Source sequence(s)
    AC017101
    Consensus CDS
    CCDS46470.1
    Related
    ENSP00000364042.3, ENST00000374907.7
  3. NM_002210.5NP_002201.2  integrin alpha-V isoform 1 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC017101
    Consensus CDS
    CCDS2292.1
    Related
    ENSP00000261023.3, ENST00000261023.8
    Conserved Domains (4) summary
    smart00191
    Location:367421
    Int_alpha; Integrin alpha (beta-propellor repeats)
    sd00039
    Location:51120
    7WD40; WD40 repeat [structural motif]
    pfam08441
    Location:467914
    Integrin_alpha2; Integrin alpha
    pfam13517
    Location:221271
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    186590056..186680902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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