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celsr1a cadherin EGF LAG seven-pass G-type receptor 1a [ Danio rerio (zebrafish) ]

Gene ID: 368436, updated on 9-Sep-2025
Official Symbol
celsr1aprovided by ZNC
Official Full Name
cadherin EGF LAG seven-pass G-type receptor 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030616-78
See related
Ensembl:ENSDARG00000069185 AllianceGenome:ZFIN:ZDB-GENE-030616-78
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
EGF; LAG; frnt; CELSR; fmi1a; celsr1; zfmi1a; fb15b11; bZ22E02.1; wu:fb15b11; si:bz6l08.1
Summary
Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Acts upstream of or within several processes, including cell migration involved in gastrulation; neural tube development; and stem cell population maintenance. Predicted to be located in plasma membrane. Is expressed in several structures, including axis; germ ring; muscle; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See celsr1a in Genome Data Viewer
Location:
chromosome: 4
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 4 NC_133179.1 (29962436..30104176, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 4 NC_007115.7 (28191614..28335352, complement)

Chromosome 4 - NC_133179.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141381639 Neighboring gene ceramide kinase Neighboring gene uncharacterized LOC141381640 Neighboring gene GRAM domain containing 4a Neighboring gene L-threonine ammonia-lyase-like Neighboring gene tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Genetic analysis of rare coding mutations of CELSR1-3 in congenital heart and neural tube defects in Chinese people. Qiao X, et al. Clin Sci (Lond), 2016 Dec 1. PMID 27756857
  2. Celsr family genes are dynamically expressed in embryonic and juvenile zebrafish. Joshi B, et al. Dev Neurobiol, 2022 Mar. PMID 35213071
  3. Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane. Witzel S, et al. J Cell Biol, 2006 Dec 4. PMID 17130287, Free PMC Article
  4. Frizzled3a and Celsr2 function in the neuroepithelium to regulate migration of facial motor neurons in the developing zebrafish hindbrain. Wada H, et al. Development, 2006 Dec. PMID 17079269
  5. Inversin (NPHP2) and Vangl2 are required for normal zebrafish cloaca formation. Wang H, et al. Biochem Biophys Res Commun, 2023 Sep 17. PMID 37352572

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish.
    Title: celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish.
  2. Fmi/Celsr therefore has a dual role in mediating two separate morphogenetic movements through its roles in mediating cell cohesion and Wnt/PCP signalling during zebrafish gastrulation.
    Title: Flamingo regulates epiboly and convergence/extension movements through cell cohesive and signalling functions during zebrafish gastrulation.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
  
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell migration involved in gastrulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cell migration involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neural tube development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
cadherin EGF LAG seven-pass G-type receptor 1; cadherin EGF LAG seven-pass G-type receptor 1a
Names
celsr4
flamingo 1a

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RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133179.1 Reference GRCz12tu Primary Assembly

    Range
    29962436..30104176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073947235.1 → XP_073803336.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X7

    UniProtKB/TrEMBL
    A0A8M3ARU0

  2. XM_073947236.1 → XP_073803337.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X8

    UniProtKB/TrEMBL
    A0A8M3ARU0

  3. XM_009300462.5 → XP_009298737.2  cadherin EGF LAG seven-pass G-type receptor 1 isoform X5

    UniProtKB/TrEMBL
    A0A8M3ARU0

  4. XM_073947234.1 → XP_073803335.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X6

    UniProtKB/TrEMBL
    A0A8M3ARU0

  5. XM_009300461.5 → XP_009298736.2  cadherin EGF LAG seven-pass G-type receptor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M3B933

  6. XM_073947233.1 → XP_073803334.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X4

    UniProtKB/TrEMBL
    A0A8M2BFV5, F1R9W4

  7. XM_009300460.5 → XP_009298735.2  cadherin EGF LAG seven-pass G-type receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M3ARK0

  8. XM_005168547.6 → XP_005168604.2  cadherin EGF LAG seven-pass G-type receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BFV5, F1R9W4
Nucleotide Protein Strain
Heading Accession and Version

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