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thoc2 THO complex 2 [ Danio rerio (zebrafish) ]

Gene ID: 368417, updated on 8-Mar-2025

Summary

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Official Symbol
thoc2provided by ZNC
Official Full Name
THO complex 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030616-54
See related
Ensembl:ENSDARG00000037503 AllianceGenome:ZFIN:ZDB-GENE-030616-54
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
THO; Tho2; fb73e08; fd21d11; wu:fb73e08; wu:fd21d11; si:bz1o18.2
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to act upstream of or within mRNA processing. Predicted to be located in nucleus. Predicted to be part of THO complex part of transcription export complex. Human ortholog(s) of this gene implicated in X-linked intellectual disability-short stature-overweight syndrome. Orthologous to human THOC2 (THO complex subunit 2). [provided by Alliance of Genome Resources, Mar 2025]
Orthologs
human mouse all
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Genomic context

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See thoc2 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (12391871..12486627)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (12085857..12180613)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487569 Neighboring gene magnesium transporter 1 Neighboring gene glutamate receptor, ionotropic, AMPA 3b Neighboring gene uncharacterized LOC108192088

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos. Huang Y, et al. Genome Biol, 2023 Jan 19. PMID 36658633, Free PMC Article
  2. Identification of nodal signaling targets by array analysis of induced complex probes. Dickmeis T, et al. Dev Dyn, 2001 Dec. PMID 11748827
  3. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Baraban SC, et al. Nat Commun, 2013. PMID 24002024, Free PMC Article
  4. Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability. LaCoursiere CM, et al. iScience, 2024 Jul 19. PMID 39021799, Free PMC Article
  5. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mRNA export from nucleus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of THO complex IEA
Inferred from Electronic Annotation
more info
  
part_of THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
THO complex subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001326547.1 → NP_001313476.1  THO complex subunit 2

    Status: VALIDATED

    Source sequence(s)
    BX470260, BX510993, BX511226, CT728579, DT063420, EB949114, EH443657
    UniProtKB/TrEMBL
    A0A8M1P3G8, F1R5B5
    Related
    ENSDARP00000099604.5, ENSDART00000115408.5

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    12391871..12486627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005157134.5 → XP_005157191.1  THO complex subunit 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B3X8, F1QXF4
    Related
    ENSDARP00000097404.3, ENSDART00000106626.5
    Conserved Domains (5) summary
    pfam11733
    Location:1442 → 1528
    NP1-WLL; Non-capsid protein NP1
    pfam08648
    Location:1442 → 1557
    DUF1777; Protein of unknown function (DUF1777)
    pfam11262
    Location:868 → 1167
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:562 → 636
    Thoc2; Transcription- and export-related complex subunit
    pfam16134
    Location:11 → 560
    THOC2_N; THO complex subunit 2 N-terminus

RNA

  1. XR_011006083.1 RNA Sequence

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394897.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    1325..32438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001003847.1: Suppressed sequence

    Description
    NM_001003847.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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