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gria3b glutamate receptor, ionotropic, AMPA 3b [ Danio rerio (zebrafish) ]

Gene ID: 368416, updated on 15-Jul-2026
Official Symbol
gria3bprovided by ZNC
Official Full Name
glutamate receptor, ionotropic, AMPA 3bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030616-53
See related
Ensembl:ENSDARG00000037498 AllianceGenome:ZFIN:ZDB-GENE-030616-53
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
AMPA; gria3; GRIN3A; glur3b; gria3.2; zfGRIA3[b]; si:bz1o18.1; SI:zC231H1.1; si:zc140k5.3
Summary
Predicted to enable AMPA glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in postsynaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in dendritic spine and postsynaptic density membrane. Is expressed in nervous system. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability 94. Orthologous to human GRIA3 (glutamate ionotropic receptor AMPA type subunit 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See gria3b in Genome Data Viewer
Location:
chromosome: 14
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 14 NC_133189.1 (13096632..13398225, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 14 NC_007125.7 (12534432..12837198, complement)

Chromosome 14 - NC_133189.1Genomic Context describing neighboring genes Neighboring gene magnesium transporter 1 Neighboring gene THO complex 2 Neighboring gene uncharacterized LOC141377630 Neighboring gene uncharacterized LOC141377698 Neighboring gene uncharacterized LOC141377697

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Identifications, classification, and evolution of the vertebrate alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit genes. Chen YC, et al. J Mol Evol, 2001 Dec. PMID 11677629
  2. Habenula as the experience-dependent controlling switchboard of behavior and attention in social conflict and learning. Okamoto H, et al. Curr Opin Neurobiol, 2021 Jun. PMID 33421772
  3. Hunger Potentiates the Habenular Winner Pathway for Social Conflict by Orexin-Promoted Biased Alternative Splicing of the AMPA Receptor Gene. Nakajo H, et al. Cell Rep, 2020 Jun 23. PMID 32579920
  4. 6-Gingerol, a Major Constituent of Zingiber officinale Rhizoma, Exerts Anticonvulsant Activity in the Pentylenetetrazole-Induced Seizure Model in Larval Zebrafish. Gawel K, et al. Int J Mol Sci, 2021 Jul 20. PMID 34299361, Free PMC Article
  5. A novel zebrafish model of hyperthermia-induced seizures reveals a role for TRPV4 channels and NMDA-type glutamate receptors. Hunt RF, et al. Exp Neurol, 2012 Sep. PMID 22735490, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hunger Potentiates the Habenular Winner Pathway for Social Conflict by Orexin-Promoted Biased Alternative Splicing of the AMPA Receptor Gene.
    Title: Hunger Potentiates the Habenular Winner Pathway for Social Conflict by Orexin-Promoted Biased Alternative Splicing of the AMPA Receptor Gene.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables AMPA glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ionotropic glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
glutamate receptor 3b
Names
glutamate receptor, ionotrophic, AMPA 3b
glutamate receptor, ionotropic, AMPA 3.2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198360.2 → NP_938174.1  glutamate receptor 3b precursor

    See identical proteins and their annotated locations for NP_938174.1

    Status: VALIDATED

    Source sequence(s)
    AF525746, BX511226, EB928785
    UniProtKB/TrEMBL
    A0A8M1PF22, A0ACM8Q2K9, Q71E60
    Related
    ENSDARP00000043179.2, ENSDART00000043180.3
    Conserved Domains (4) summary
    cd13715
    Location:412 → 794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:544 → 824
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:36 → 379
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:25 → 396
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133189.1 Reference GRCz12tu Primary Assembly

    Range
    13096632..13398225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005157133.5 → XP_005157190.1  glutamate receptor 3b isoform X1

    UniProtKB/TrEMBL
    A0A286Y9Q6, A0A8M2B408
    Related
    ENSDARP00000143892.1
    Conserved Domains (4) summary
    cd13715
    Location:412 → 794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:544 → 824
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:36 → 379
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:25 → 396
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  2. XM_005157132.5 → XP_005157189.1  glutamate receptor 3b isoform X2

    See identical proteins and their annotated locations for XP_005157189.1

    UniProtKB/TrEMBL
    A0A8M1PF22, A0ACM8Q2K9, Q71E60
    Related
    ENSDARP00000133635.1
    Conserved Domains (4) summary
    cd13715
    Location:412 → 794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:544 → 824
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:36 → 379
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:25 → 396
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  3. XM_009307719.5 → XP_009305994.1  glutamate receptor 3b isoform X4

    UniProtKB/TrEMBL
    A0A8M3B5M3
    Conserved Domains (4) summary
    cd13715
    Location:412 → 766
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:544 → 764
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:36 → 379
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:25 → 396
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  4. XM_021480987.3 → XP_021336662.1  glutamate receptor 3b isoform X3

    UniProtKB/TrEMBL
    A0A8M9PZ43
    Conserved Domains (2) summary
    cd13715
    Location:412 → 794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cl10011
    Location:25 → 396
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RNA

  1. XR_002459908.3 RNA Sequence

  2. XR_002459909.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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