ptenb phosphatase and tensin homolog B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptenbprovided by ZNC
Official Full Name: phosphatase and tensin homolog Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-47
See related: Ensembl:ENSDARG00000056623 AllianceGenome:ZFIN:ZDB-GENE-030616-47
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pten; fa11a08; fb73f10; fc83f12; fd16b10; fk90e11; wu:fa11a08; wu:fb73f10; wu:fc83f12; wu:fd16b10; wu:fk90e11; si:bz1g13.4
Summary: Enables lipid phosphatase activity. Acts upstream of or within several processes, including lifelong otolith mineralization; negative regulation of angiogenesis; and phosphatidylinositol dephosphorylation. Predicted to be located in several cellular components, including PML body; dendritic spine; and postsynaptic density. Predicted to be active in several cellular components, including cytosol; nucleus; and plasma membrane. Is expressed in several structures, including adaxial cell; blastomere; nervous system; neural rod; and pectoral fin. Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	12	NC_133187.1 (18995031..19021132, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (17398087..17424188, complement)

Chromosome 12 - NC_133187.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ndrg1b and fam49ab are 2 new modulators of PTEN signaling that control lymphoid differentiation in the zebrafish thymus.
Title: Ndrg1b and fam49ab modulate the PTEN pathway to control T-cell lymphopoiesis in the zebrafish.
We further showed that PTEN knockdown in MCF-7 cells could increase cell migration in the xenograft zebrafish model. Our findings reveal new therapeutic targets for breast cancer patients with PTEN insufficiency.
Title: PTEN Insufficiency Increases Breast Cancer Cell Metastasis In Vitro and In Vivo in a Xenograft Zebrafish Model.
the role of Pten during zebrafish embryonic development
Title: Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development.
Vegfaa has a crucial role in angiogenesis and vegfaa expression was upregulated in embryos lacking functional Pten.
Title: Loss of Pten promotes angiogenesis and enhanced vegfaa expression in zebrafish.
Pten has an essential role in the balance between proliferation and differentiation of blood cells.
Title: Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish.
ptena(+/-)ptenb(-/-) fish develop tumors at a relatively high incidence (10.2%) and most tumors developed close to the eye (26/30). The tumor masses were associated with the retrobulbar vascular network and diagnosed as hemangiosarcomas.
Title: Haploinsufficiency of the genes encoding the tumor suppressor Pten predisposes zebrafish to hemangiosarcoma.
These results suggest that Ptenb by antagonizing PI3 kinase and its downstream Akt1 and Cdc42 to regulate actin polymerization that is critical for proper cell motility and migration control during gastrulation in zebrafish.
Title: Ptenb mediates gastrulation cell movements via Cdc42/AKT1 in zebrafish.
An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 axis controls myeloid development and transformation.
Title: An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 axis controls myeloid development and transformation.
An embryonic model of phosphatase/tensin homolog on chromosome 10-induced putative kinase 1 (PINK1) deficiency demonstrates general developmental delay aggravated by severe mispatterning of axonal scaffolds and reduction of neuronal populations.
Title: Loss of PINK1 function affects development and results in neurodegeneration in zebrafish.
Whereas Ptena and Ptenb have redundant functions in embryonic development, they apparently do not have completely overlapping functions later in life.
Title: Zebrafish pten genes have overlapping and non-redundant functions in tumorigenesis and embryonic development.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

fc83f12.x1 (e-PCR)
- UniSTS:194613

fd16b10.x1 (e-PCR)
- UniSTS:204206

fk90e11.x1 (e-PCR)
- UniSTS:201699

fe26c10.x1 (e-PCR)
- UniSTS:196351

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables lipid phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables lipid phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell motility	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dephosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lifelong otolith mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myeloid cell activation involved in immune response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within myeloid cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell communication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cellular component organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of developmental process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of multicellular organismal process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphatidylinositol dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphatidylinositol dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macromolecule metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of biological quality	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Names: phosphatase and tensin homolog (mutated in multiple advanced cancers 1); phosphatase and tensin homolog B (mutated in multiple advanced cancers 1)

NP_001001822.1

EC 3.1.3.67

NP_001410617.1

EC 3.1.3.67

XP_073773555.1

EC 3.1.3.67

XP_073773556.1

EC 3.1.3.67

XP_073773557.1

EC 3.1.3.67

XP_073773558.1

EC 3.1.3.67

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001822.3 → NP_001001822.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 2

See identical proteins and their annotated locations for NP_001001822.1

Status: VALIDATED

Source sequence(s)

AY398671, BF156713, CA471751, CT589272, CT638432, EB779477, EE327956, EG574733, EH575536, GDQH01009434

UniProtKB/TrEMBL

Q32PW0, Q7ZZ56

Related

ENSDARP00000073600.3, ENSDART00000079144.5

Conserved Domains (2) summary

smart00404
Location:92 → 182

PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif

pfam10409
Location:188 → 348

PTEN_C2; C2 domain of PTEN tumour-suppressor protein
NM_001423688.1 → NP_001410617.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 1

Status: VALIDATED

Source sequence(s)

BF156713, CA471751, CT589272, CT638432, EB779477, EE327956, EG574733, EH575536, GDQH01009434

UniProtKB/TrEMBL

A0AB13A9H5

Related

ENSDARP00000073594.2, ENSDART00000079138.4

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

NC_133187.1 Reference GRCz12tu Primary Assembly

Range

18995031..19021132 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_073917456.1 → XP_073773557.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2
XM_073917454.1 → XP_073773555.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1
XM_073917457.1 → XP_073773558.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2
XM_073917455.1 → XP_073773556.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1