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arhgef1a Rho guanine nucleotide exchange factor (GEF) 1a [ Danio rerio (zebrafish) ]

Gene ID: 368266, updated on 22-Nov-2020

Summary

Official Symbol
arhgef1aprovided by ZNC
Official Full Name
Rho guanine nucleotide exchange factor (GEF) 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030722-5
See related
Ensembl:ENSDARG00000040380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
arhge; cb473; arhgef1; zgc:158261
Orthologs

Genomic context

See arhgef1a in Genome Data Viewer
Location:
chromosome: 19
Exon count:
31
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (11039512..11157661, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (11121514..11188317, complement)
103 previous assembly Zv9 (GCF_000002035.4) 19 NC_007130.5 (11529762..11647917, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene cytosolic phospholipase A2 zeta-like Neighboring gene microseminoprotein, prostate associated 2 Neighboring gene tropomyosin 3 Neighboring gene si:dkey-240h12.4 Neighboring gene uncharacterized LOC103909207 Neighboring gene si:ch73-109i22.2

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 1a; rho guanine nucleotide exchange factor 2
Names
rho guanine nucleotide exchange factor (GEF) 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081631.2NP_001075100.1  rho guanine nucleotide exchange factor 1a

    See identical proteins and their annotated locations for NP_001075100.1

    Status: VALIDATED

    Source sequence(s)
    CT573147
    UniProtKB/TrEMBL
    A2RUX1
    Related
    ENSDARP00000059101.6, ENSDART00000059102.7
    Conserved Domains (4) summary
    cd00029
    Location:4691
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd13393
    Location:476593
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:479578
    PH; PH domain
    pfam00621
    Location:245437
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    11039512..11157661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021468005.1XP_021323680.1  rho guanine nucleotide exchange factor 2 isoform X1

    Conserved Domains (3) summary
    cd00029
    Location:260305
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:456650
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:690807
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
  2. XM_021468006.1XP_021323681.1  rho guanine nucleotide exchange factor 2 isoform X2

    Conserved Domains (3) summary
    cd00029
    Location:260305
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:446640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:680797
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
  3. XM_009294091.3XP_009292366.1  rho guanine nucleotide exchange factor 2 isoform X3

    Conserved Domains (3) summary
    pfam00169
    Location:418517
    PH; PH domain
    pfam00621
    Location:184376
    RhoGEF; RhoGEF domain
    cl17171
    Location:415532
    PH-like; Pleckstrin homology-like domain
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