Format

Send to:

Choose Destination

tbx1 T-box transcription factor 1 [ Danio rerio (zebrafish) ]

Gene ID: 368206, updated on 3-Oct-2021

Summary

Official Symbol
tbx1provided by ZNC
Official Full Name
T-box transcription factor 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030805-5
See related
Ensembl:ENSDARG00000031891
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:136724; mp:zf637-3-000616
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See tbx1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (15201823..15215479)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (14701844..14716157)
103 previous assembly Zv9 (GCF_000002035.4) 5 NC_007116.5 (16905730..16919394)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene si:ch211-244o22.2 Neighboring gene sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C Neighboring gene guanine nucleotide binding protein (G protein), beta polypeptide 1-like Neighboring gene thioredoxin reductase 2, tandem duplicate 2

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

General gene information

Homology

Clone Names

  • MGC136724

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cartilage morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic heart tube morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic viscerocranium morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within heart looping IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural crest cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pharyngeal muscle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pharyngeal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within pharyngeal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pharyngeal system development ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of secondary heart field cardioblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within semicircular canal morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in thymus development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
T-box transcription factor TBX1
Names
T-box 1
T-box protein 1
van gogh
vgo

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183339.1NP_899182.1  T-box transcription factor TBX1

    See identical proteins and their annotated locations for NP_899182.1

    Status: PROVISIONAL

    Source sequence(s)
    AY151388
    UniProtKB/Swiss-Prot
    Q8AXX2
    Related
    ENSDARP00000040825.5, ENSDART00000040826.6
    Conserved Domains (1) summary
    cd00182
    Location:106296
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    15201823..15215479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005168611.4XP_005168668.1  T-box transcription factor TBX1 isoform X1

    Related
    ENSDARP00000118808.1, ENSDART00000144915.3
    Conserved Domains (1) summary
    cd00182
    Location:165355
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
  2. XM_009301230.3XP_009299505.1  T-box transcription factor TBX1 isoform X2

    Conserved Domains (1) summary
    cd00182
    Location:148338
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
Support Center