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Rorc RAR-related orphan receptor C [ Rattus norvegicus (Norway rat) ]

Gene ID: 368158, updated on 12-Aug-2018

Summary

Official Symbol
Rorcprovided by RGD
Official Full Name
RAR-related orphan receptor Cprovided by RGD
Primary source
RGD:1595785
See related
Ensembl:ENSRNOG00000020836
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Thymus (RPKM 399.9), Liver (RPKM 124.0) and 5 other tissues See more
Orthologs

Genomic context

See Rorc in Genome Data Viewer
Location:
2q34
Exon count:
12
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (195612471..195636797)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene thioesterase superfamily member 5 Neighboring gene C2 calcium-dependent domain containing 4D Neighboring gene leucine rich repeat and Ig domain containing 4 Neighboring gene tudor and KH domain containing Neighboring gene cytochrome c, somatic-like Neighboring gene ornithine decarboxylase antizyme 3

Genomic regions, transcripts, and products

Genomic Sequence:
NC_005101.4 Chromosome 2 Reference Rnor_6.0 Primary Assembly

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Circadian rhythm, organism-specific biosystem (from KEGG)
    Circadian rhythm, organism-specific biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
  • Circadian rhythm, conserved biosystem (from KEGG)
    Circadian rhythm, conserved biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
    Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
    Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Nuclear Receptor transcription pathway, organism-specific biosystem (from REACTOME)
    Nuclear Receptor transcription pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Nuclear Receptors, organism-specific biosystem (from WikiPathways)
    Nuclear Receptors, organism-specific biosystemNuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, th...
  • Th17 cell differentiation, organism-specific biosystem (from KEGG)
    Th17 cell differentiation, organism-specific biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
  • Th17 cell differentiation, conserved biosystem (from KEGG)
    Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...

General gene information

Markers

Clone Names

  • MGC189525

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
molecular_function ND
No biological Data available
more info
 
nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 
oxysterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxysterol binding IEA
Inferred from Electronic Annotation
more info
 
oxysterol binding ISO
Inferred from Sequence Orthology
more info
 
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
steroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor activity, direct ligand regulated sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Peyer's patch development ISO
Inferred from Sequence Orthology
more info
 
T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
 
T-helper 17 cell differentiation ISO
Inferred from Sequence Orthology
more info
 
T-helper cell differentiation ISO
Inferred from Sequence Orthology
more info
 
adipose tissue development ISO
Inferred from Sequence Orthology
more info
 
alpha-beta T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
cell differentiation ISO
Inferred from Sequence Orthology
more info
 
cellular response to sterol IEA
Inferred from Electronic Annotation
more info
 
cellular response to sterol ISO
Inferred from Sequence Orthology
more info
 
circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
interleukin-17 production ISO
Inferred from Sequence Orthology
more info
 
interleukin-17 secretion ISO
Inferred from Sequence Orthology
more info
 
intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
lymph node development ISO
Inferred from Sequence Orthology
more info
 
mucosal-associated lymphoid tissue development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of thymocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of gamma-delta T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of steroid metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription involved in cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
nuclear body IEA
Inferred from Electronic Annotation
more info
 
nuclear body ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nuclear receptor ROR-gamma
Names
RAR-related orphan receptor gamma

NCBI Reference Sequences (RefSeq)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    195612471..195636797
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591313.1XP_017446802.1  nuclear receptor ROR-gamma isoform X3

  2. XM_006232926.3XP_006232988.2  nuclear receptor ROR-gamma isoform X1

    Conserved Domains (2) summary
    cd06939
    Location:258496
    NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
    cd06968
    Location:24118
    NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
  3. XM_008761339.1XP_008759561.1  nuclear receptor ROR-gamma isoform X2

    UniProtKB/TrEMBL
    A0A0G2QC01
    Related
    ENSRNOP00000058884.3, ENSRNOT00000067042.3
    Conserved Domains (2) summary
    cd06939
    Location:237475
    NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
    cd06968
    Location:497
    NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
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