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ITGAD integrin subunit alpha D [ Homo sapiens (human) ]

Gene ID: 3681, updated on 23-Nov-2023

Summary

Official Symbol
ITGADprovided by HGNC
Official Full Name
integrin subunit alpha Dprovided by HGNC
Primary source
HGNC:HGNC:6146
See related
Ensembl:ENSG00000156886 MIM:602453; AllianceGenome:HGNC:6146
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADB2; CD11D
Summary
This gene belongs to the beta-2 integrin family of membrane glycoproteins, which are are composed of non-covalently linked alpha and beta subunits to form a heterodimer. It encodes the alpha subunit of the cell surface heterodimers and is involved in the activation and adhesion functions of leukocytes. The gene is located about 11kb downstream of the integrin subunit alpha X gene, another member of the integrin family. It is expressed in the tissue and circulating myeloid leukocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression
Biased expression in spleen (RPKM 11.2), lymph node (RPKM 2.1) and 2 other tissues See more
Orthologs
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Genomic context

See ITGAD in Genome Data Viewer
Location:
16p11.2
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (31393335..31426505)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (31780736..31813905)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31404656..31437826)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:31276375-31277574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31282603-31283128 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31283129-31283654 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:31284654-31285853 Neighboring gene integrin subunit alpha M Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:31295357-31296556 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:31336636-31336863 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10761 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10763 Neighboring gene integrin subunit alpha X pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:31379880-31380486 Neighboring gene integrin subunit alpha X Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31393428-31393928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31393929-31394429 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31446802-31447302 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:31447884-31448054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31453737-31454532 Neighboring gene cytochrome c oxidase subunit 6A2 Neighboring gene zinc finger protein 843

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ39841

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cell surface IC
Inferred by Curator
more info
PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of integrin complex TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
integrin alpha-D
Names
CD11 antigen-like family member D
beta-2 integrin alphaD subunit
leukointegrin alpha D

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050624.2 RefSeqGene

    Range
    5002..38172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001318185.2NP_001305114.1  integrin alpha-D isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC026471, AC093520
    UniProtKB/TrEMBL
    Q59H14
    Conserved Domains (4) summary
    smart00191
    Location:453495
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11251139
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:617958
    Integrin_alpha2; Integrin alpha
  2. NM_005353.3NP_005344.2  integrin alpha-D isoform 2 precursor

    See identical proteins and their annotated locations for NP_005344.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1.
    Source sequence(s)
    AC026471, AC093520
    Consensus CDS
    CCDS32438.1
    UniProtKB/Swiss-Prot
    Q13349, Q15575, Q15576
    UniProtKB/TrEMBL
    Q59H14
    Related
    ENSP00000373854.2, ENST00000389202.3
    Conserved Domains (4) summary
    smart00191
    Location:453509
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11241138
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:616957
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    31393335..31426505
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545835.4XP_011544137.1  integrin alpha-D isoform X1

    UniProtKB/TrEMBL
    Q59H14
    Conserved Domains (4) summary
    smart00191
    Location:464506
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11531167
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:628933
    Integrin_alpha2; Integrin alpha
  2. XM_017023215.3XP_016878704.1  integrin alpha-D isoform X6

    UniProtKB/TrEMBL
    Q59H14
  3. XM_011545839.3XP_011544141.1  integrin alpha-D isoform X5

    UniProtKB/TrEMBL
    Q59H14
    Conserved Domains (4) summary
    smart00191
    Location:464506
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11361150
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:628969
    Integrin_alpha2; Integrin alpha
  4. XM_011545837.3XP_011544139.1  integrin alpha-D isoform X3

    UniProtKB/TrEMBL
    Q59H14
    Conserved Domains (4) summary
    smart00191
    Location:464506
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11521166
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:628932
    Integrin_alpha2; Integrin alpha
  5. XM_011545844.4XP_011544146.1  integrin alpha-D isoform X11

    UniProtKB/TrEMBL
    Q59H14
    Conserved Domains (3) summary
    smart00191
    Location:464506
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:961975
    Integrin_alpha; Integrin alpha cytoplasmic region
  6. XM_011545836.4XP_011544138.1  integrin alpha-D isoform X2

    UniProtKB/TrEMBL
    Q59H14
    Conserved Domains (4) summary
    smart00191
    Location:464520
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11521166
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:627932
    Integrin_alpha2; Integrin alpha
  7. XM_011545838.3XP_011544140.1  integrin alpha-D isoform X4

    UniProtKB/TrEMBL
    Q59H14
    Conserved Domains (4) summary
    smart00191
    Location:453495
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11421156
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:617922
    Integrin_alpha2; Integrin alpha
  8. XM_047434071.1XP_047290027.1  integrin alpha-D isoform X8

    UniProtKB/TrEMBL
    Q59H14
  9. XM_011545841.3XP_011544143.1  integrin alpha-D isoform X7

    UniProtKB/TrEMBL
    Q59H14
    Conserved Domains (4) summary
    smart00191
    Location:453509
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11231137
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:616956
    Integrin_alpha2; Integrin alpha
  10. XM_011545842.4XP_011544144.1  integrin alpha-D isoform X9

    UniProtKB/TrEMBL
    Q59H14
    Conserved Domains (4) summary
    smart00191
    Location:377419
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:10661080
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:541846
    Integrin_alpha2; Integrin alpha
  11. XM_011545847.4XP_011544149.1  integrin alpha-D isoform X14

    Conserved Domains (2) summary
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:741755
    Integrin_alpha; Integrin alpha cytoplasmic region
  12. XM_011545843.4XP_011544145.1  integrin alpha-D isoform X10

    UniProtKB/TrEMBL
    Q59H14
    Conserved Domains (3) summary
    smart00191
    Location:464506
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:628933
    Integrin_alpha2; Integrin alpha
  13. XM_011545845.4XP_011544147.1  integrin alpha-D isoform X12

    Conserved Domains (2) summary
    smart00191
    Location:464506
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
  14. XM_011545848.4XP_011544150.1  integrin alpha-D isoform X15

    Conserved Domains (2) summary
    smart00191
    Location:464506
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
  15. XM_011545846.4XP_011544148.1  integrin alpha-D isoform X13

    Conserved Domains (2) summary
    smart00191
    Location:464506
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

RNA

  1. XR_950791.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    31780736..31813905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380250.1XP_054236225.1  integrin alpha-D isoform X1

    UniProtKB/TrEMBL
    Q59H14
  2. XM_054380255.1XP_054236230.1  integrin alpha-D isoform X6

    UniProtKB/TrEMBL
    Q59H14
  3. XM_054380254.1XP_054236229.1  integrin alpha-D isoform X5

    UniProtKB/TrEMBL
    Q59H14
  4. XM_054380252.1XP_054236227.1  integrin alpha-D isoform X3

    UniProtKB/TrEMBL
    Q59H14
  5. XM_054380260.1XP_054236235.1  integrin alpha-D isoform X11

    UniProtKB/TrEMBL
    Q59H14
  6. XM_054380251.1XP_054236226.1  integrin alpha-D isoform X2

    UniProtKB/TrEMBL
    Q59H14
  7. XM_054380253.1XP_054236228.1  integrin alpha-D isoform X4

    UniProtKB/TrEMBL
    Q59H14
  8. XM_054380257.1XP_054236232.1  integrin alpha-D isoform X8

    UniProtKB/TrEMBL
    Q59H14
  9. XM_054380256.1XP_054236231.1  integrin alpha-D isoform X7

    UniProtKB/TrEMBL
    Q59H14
  10. XM_054380258.1XP_054236233.1  integrin alpha-D isoform X9

    UniProtKB/TrEMBL
    Q59H14
  11. XM_054380263.1XP_054236238.1  integrin alpha-D isoform X14

  12. XM_054380259.1XP_054236234.1  integrin alpha-D isoform X10

    UniProtKB/TrEMBL
    Q59H14
  13. XM_054380261.1XP_054236236.1  integrin alpha-D isoform X12

  14. XM_054380264.1XP_054236239.1  integrin alpha-D isoform X15

  15. XM_054380262.1XP_054236237.1  integrin alpha-D isoform X13

RNA

  1. XR_008489085.1 RNA Sequence