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Lis-1 Lissencephaly-1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36791, updated on 8-Oct-2018

Summary

Official Symbol
Lis-1provided by FlyBase
Official Full Name
Lissencephaly-1provided by FlyBase
Primary source
FLYBASE:FBgn0015754
Locus tag
Dmel_CG8440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8440; D-Lis1; Dlis-1; DLis-1; DLIS-1; dLis1; Dlis1; DLis1; DLIS1; Dmel\CG8440; DmLIS1; l(2)k13209; l(2R)W8; Lis 1; lis-1; LIS-1; lis1; Lis1; n(2)k11702

Genomic context

See Lis-1 in Genome Data Viewer
Location:
52F4-52F5; 2-78 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16178826..16185103)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12066331..12072608)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Protein tyrosine phosphatase 52F Neighboring gene uncharacterized protein Neighboring gene clueless Neighboring gene calypso

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
ATPase activity, coupled ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
dynein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
dynein complex binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
axo-dendritic transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
brain morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
centrosome separation IMP
Inferred from Mutant Phenotype
more info
PubMed 
chorion-containing eggshell pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
clathrin-dependent endocytosis involved in vitellogenesis IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic transport, nurse cell to oocyte IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
dorsal appendage formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of mitotic spindle orientation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
female germ-line cyst formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
fusome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
germarium-derived cystoblast division IMP
Inferred from Mutant Phenotype
more info
PubMed 
germarium-derived oocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
germarium-derived oocyte fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular mRNA localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
kinetochore organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule organizing center organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based movement ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mitotic cell cycle checkpoint IGI
Inferred from Genetic Interaction
more info
PubMed 
mitotic cell cycle checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
muscle cell cellular homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
muscle cell cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
mushroom body development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear migration along microtubule IGI
Inferred from Genetic Interaction
more info
PubMed 
nucleus localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
oocyte fate determination IGI
Inferred from Genetic Interaction
more info
PubMed 
oocyte nucleus migration involved in oocyte dorsal/ventral axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
oogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ovarian fusome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
photoreceptor cell axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization IGI
Inferred from Genetic Interaction
more info
PubMed 
protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of translation by machinery localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
retrograde axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retrograde axonal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
rhabdomere development IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
stem cell population maintenance IDA
Inferred from Direct Assay
more info
PubMed 
transport along microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dynactin complex IDA
Inferred from Direct Assay
more info
PubMed 
dynein complex IDA
Inferred from Direct Assay
more info
PubMed 
dynein complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
kinetochore microtubule IDA
Inferred from Direct Assay
more info
PubMed 
microtubule associated complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole centrosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Lissencephaly-1
Names
CG8440-PA
CG8440-PB
CG8440-PF
CG8440-PG
Lis-1-PA
Lis-1-PB
Lis-1-PF
Lis-1-PG
Paf-AHbeta
lissencephaly-1
platelet-activating factor acetylhydrolase Ib beta-subunit homolog
NP_001246361.1
NP_477160.1
NP_788370.1
NP_995852.1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16178826..16185103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057812.5NP_477160.1  Lissencephaly-1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477160.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7KNS3
    UniProtKB/TrEMBL
    A0A0B4K812
    Related
    FBpp0086375, FBtr0087236
    Conserved Domains (4) summary
    smart00667
    Location:940
    LisH; Lissencephaly type-1-like homology motif
    COG2319
    Location:97411
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:100409
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111148
    7WD40; WD40 repeat [structural motif]
  2. NM_001259432.2NP_001246361.1  Lissencephaly-1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246361.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7KNS3
    UniProtKB/TrEMBL
    A0A0B4K812
    Related
    FBpp0293289, FBtr0304747
    Conserved Domains (4) summary
    smart00667
    Location:940
    LisH; Lissencephaly type-1-like homology motif
    COG2319
    Location:97411
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:100409
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111148
    7WD40; WD40 repeat [structural motif]
  3. NM_176190.2NP_788370.1  Lissencephaly-1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788370.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7KNS3
    UniProtKB/TrEMBL
    A0A0B4K812
    Related
    FBpp0086379, FBtr0087240
    Conserved Domains (4) summary
    smart00667
    Location:940
    LisH; Lissencephaly type-1-like homology motif
    COG2319
    Location:97411
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:100409
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111148
    7WD40; WD40 repeat [structural motif]
  4. NM_206130.2NP_995852.1  Lissencephaly-1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995852.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7KNS3
    UniProtKB/TrEMBL
    A0A0B4K812
    Related
    FBpp0089100, FBtr0087241
    Conserved Domains (4) summary
    smart00667
    Location:940
    LisH; Lissencephaly type-1-like homology motif
    COG2319
    Location:97411
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:100409
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111148
    7WD40; WD40 repeat [structural motif]
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