Rho1 Rho1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rho1provided by FlyBase
Official Full Name: Rho1provided by FlyBase
Primary source: FLYBASE:FBgn0014020
Locus tag: Dmel_CG8416
See related: AllianceGenome:FB:FBgn0014020
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 19549712; 8416; AAF01186; CG8416; D-Rho1; Dm Rho1; Dmel\CG8416; DmRHO-A; dnRho; DRho; dRho1; Drho1; DRho1; dRhoA; DrhoA; DRhoA; E3.10/J3.8; l(2)52Fa; l(2)k02107b; n(2)k07236; P48148; rho; Rho; RHO; Rho A; Rho GTPase; rho1; RHO1; rhoA; RhoA; RHOA; RhoN19
Summary: Enables GTPase activity and kinase binding activity. Involved in several processes, including embryonic morphogenesis; neurogenesis; and open tracheal system development. Located in apical cortex; cell hair; and cell-cell contact zone. Is active in cleavage furrow rim. Colocalizes with apical plasma membrane. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; gland; mesoderm; and nephrocyte. Used to study neurodegenerative disease and peroxisomal biogenesis disorder. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to several human genes including RHOA (ras homolog family member A) and RHOC (ras homolog family member C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 52E5-52E5; 2-77 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16102687..16107229)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (11990192..11994734)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PFTK1 kinase regulates axogenesis during development via RhoA activation.
Title: PFTK1 kinase regulates axogenesis during development via RhoA activation.
Septins regulate border cell surface geometry, shape, and motility downstream of Rho in Drosophila.
Title: Septins regulate border cell surface geometry, shape, and motility downstream of Rho in Drosophila.
The Pebble/Rho1/Anillin pathway controls polyploidization and axonal wrapping activity in the glial cells of the Drosophila eye.
Title: The Pebble/Rho1/Anillin pathway controls polyploidization and axonal wrapping activity in the glial cells of the Drosophila eye.
Combinatorial patterns of graded RhoA activation and uniform F-actin depletion promote tissue curvature.
Title: Combinatorial patterns of graded RhoA activation and uniform F-actin depletion promote tissue curvature.
Rho1 activation recapitulates early gastrulation events in the ventral, but not dorsal, epithelium of Drosophila embryos.
Title: Rho1 activation recapitulates early gastrulation events in the ventral, but not dorsal, epithelium of Drosophila embryos.
Microtubule plus-end-associated centralspindlin recruits a cortical pool of Drosophila melanogaster ECT2 upon physical contact to activate RhoA and to trigger localized contractility.
Title: Microtubule plus-ends act as physical signaling hubs to activate RhoA during cytokinesis.
Recruitment of active Rho1 to the fused vesicle triggers activation of the formin Diaphanous and actin nucleation.
Title: Feedback inhibition of actin on Rho mediates content release from large secretory vesicles.
Modular activation of Rho1 by GPCR signalling imparts polarized myosin II activation during morphogenesis
Title: Modular activation of Rho1 by GPCR signalling imparts polarized myosin II activation during morphogenesis.
Study identified circadian rhythms in Rho1 GTPase activity in s-LNv axons that are regulated by rhythmic transcription of Pura, a Rho1 GEF. Pura activates Rho1 to retract s-LNv axons, decrease active zone numbers and reduce s-LNvs' influence on the clock network. Thus, study links transcription, plasticity, network hierarchy and behavior.
Title: Circadian Rhythms in Rho1 Activity Regulate Neuronal Plasticity and Network Hierarchy.
Developmental hemocyte migration requires the interaction of Rho1 with its downstream effector Wash, a Wiskott-Aldrich syndrome family protein.
Title: Wash functions downstream of Rho1 GTPase in a subset of Drosophila immune cell developmental migrations.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables GTPase activity	TAS Traceable Author Statement more info	PubMed
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament bundle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin-mediated cell contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in adherens junction maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apical constriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell elongation involved in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell projection organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellularization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in dendrite self-avoidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in dorsal closure, amnioserosa morphology change	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure, leading edge cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure, spreading of leading edge cells	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytic recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of planar polarity of embryonic epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of actin cytoskeleton polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gastrulation involving germ band extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-band extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing hair organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing hair organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lumen formation, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanization defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic actomyosin contractile ring assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis, division site positioning	IEP Inferred from Expression Pattern more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in muscle attachment	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of wound healing	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in posterior midgut invagination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization involved in establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to adherens junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pseudocleavage involved in syncytial blastoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Malpighian tubule size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actomyosin structure organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of embryonic cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of myoblast fusion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of tube length, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in spiracle morphogenesis, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tracheal pit formation in open tracheal system	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ventral furrow formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	HMP more info	PubMed
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell hair	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell contact zone	IDA Inferred from Direct Assay more info	PubMed
is_active_in cleavage furrow rim	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: Rho1

Names: CG8416-PA; CG8416-PB; CG8416-PC; CG8416-PD; CG8416-PF; CG8416-PG; Rho GTPase; Rho1-PA; Rho1-PB; Rho1-PC; Rho1-PD; Rho1-PF; Rho1-PG; RhoA; RhoA kinase; rho kinase; rho1; rho1 kinase

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

16102687..16107229

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_134308.3 → NP_599135.1 Rho1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_599135.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZI6, P48148, Q0E958, Q9V3J0

Related

FBpp0086354

Conserved Domains (1) summary

cd01870
Location:5 → 179

RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
NM_206128.2 → NP_995850.1 Rho1, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995850.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZI6, P48148, Q0E958, Q9V3J0

Conserved Domains (1) summary

cd01870
Location:5 → 179

RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
NM_134309.2 → NP_599136.1 Rho1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_599136.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZI6, P48148, Q0E958, Q9V3J0

Related

FBpp0086355

Conserved Domains (1) summary

cd01870
Location:5 → 179

RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
NM_057750.4 → NP_477098.1 Rho1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477098.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZI6, P48148, Q0E958, Q9V3J0

Related

FBpp0086353

Conserved Domains (1) summary

cd01870
Location:5 → 179

RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
NM_206127.2 → NP_995849.1 Rho1, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995849.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZI6, P48148, Q0E958, Q9V3J0

Conserved Domains (1) summary

cd01870
Location:5 → 179

RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
NM_166139.3 → NP_725524.1 Rho1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725524.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZI6, P48148, Q0E958, Q9V3J0

Related

FBpp0086356

Conserved Domains (1) summary

cd01870
Location:5 → 179

RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC