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Cyp6a9 Cytochrome P450 6a9 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36663, updated on 4-Apr-2024

Summary

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Official Symbol
Cyp6a9provided by FlyBase
Official Full Name
Cytochrome P450 6a9provided by FlyBase
Primary source
FLYBASE:FBgn0013771
Locus tag
Dmel_CG10246
See related
AllianceGenome:FB:FBgn0013771
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
6a9; CG10246; Cyp6A9; CYP6a9; CYP6A9; Cyt-P450-rAF4; Dmel\CG10246; P-450; P450
Summary
Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. Is expressed in adult head. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough); CYP3A4 (cytochrome P450 family 3 subfamily A member 4); and CYP3A43 (cytochrome P450 family 3 subfamily A member 43). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
51D1-51D1; 2-73 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14879356..14881372, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10766861..10768877, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 6a17 Neighboring gene Cytochrome P450 6a23 Neighboring gene Cytochrome P450 6a19 Neighboring gene Cytochrome P450 6a20 Neighboring gene Cytochrome P450 6a21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and sequence analysis of cytochrome P450 12B1: the first mitochondrial insect P450 with homology to 1 alpha,25 dihydroxy-D3 24-hydroxylase. Danielson PB, et al. Insect Biochem Mol Biol, 1997 Jun. PMID 9304797
  2. Cytochromes P450 and insecticide resistance. Scott JG. Insect Biochem Mol Biol, 1999 Sep. PMID 10510498
  3. Cytochrome P450 monooxygenases and insecticide resistance in insects. Bergé JB, et al. Philos Trans R Soc Lond B Biol Sci, 1998 Oct 29. PMID 10021770, Free PMC Article
  4. Three second chromosome-linked clustered Cyp6 genes show differential constitutive and barbital-induced expression in DDT-resistant and susceptible strains of Drosophila melanogaster. Maitra S, et al. Gene, 1996 Nov 21. PMID 8973362
  5. Insect cytochromes P450: diversity, insecticide resistance and tolerance to plant toxins. Scott JG, et al. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol, 1998 Nov. PMID 9972456

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 6a9
Names
CG10246-PB
Cyp6a9-PB
cytochrome P450 related AF4
cytochrome P450-6a9
NP_523748.2
  • non-AUG (AUA) translation initiation, point mutation, may be evolving pseudogene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14879356..14881372 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079024.3 → NP_523748.2  cytochrome P450 6a9 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523748.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27594, Q8MRY8, Q9V772
    Conserved Domains (1) summary
    pfam00067
    Location:35 → 499
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q27594.3 Q27594

Gene LinkOut

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